AI Article Synopsis
- The study explored alternative diagnostic methods for iron deficiency in hemodialysis patients, focusing on reticulocyte hemoglobin content (CHret) and hypochromic RBC percentage (HYPO%), compared to traditional biochemical tests.
- Reticulocyte indices and erythrocyte parameters showed better predictive abilities for iron deficiency, with area under the curve (AUC) values indicating their effectiveness.
- Results suggest that newly proposed measures, Ret-He and %Hypo-He, are clinically useful and provide information comparable to traditional methods in assessing iron responsiveness.
Article Abstract
To diagnose iron deficiency in patients undergoing hemodialysis, the percentage of hypochromic RBCs (with cellular hemoglobin concentration <280 g/L [HYPO%]) and mean reticulocyte hemoglobin content (CHret) provided by the Siemens ADVIA 120 and 2120 analyzers (Siemens Diagnostic Solutions, Tarrytown, NY) were proposed as alternatives to biochemical tests. Sysmex, with its XE-5000 analyzer (Sysmex, Kobe, Japan), also proposed the percentage of erythrocytes with cellular hemoglobin content lower than 17 pg (%Hypo-He) and equivalent of the mean reticulocyte hemoglobin content (Ret-He) with similar clinical applications. Our aim was to verify the clinical usefulness of the biochemical and cellular parameters as predictors of iron deficiency in patients undergoing long-term hemodialysis. We studied 69 patients undergoing hemodialysis 3 times weekly. The baseline values of serum ferritin and percentage of transferrin saturation were poor predictors of iron responsiveness. Better ability was demonstrated by reticulocyte indices (area under the curve [AUC], 0.74 for CHret and 0.72 for Ret-He; best cutoff values, 31.2 and 30.6 pg, respectively) and erythrocyte parameters (AUC, 0.72 for HYPO% and 0.68 for %Hypo-He; best cutoff values, 5.8 and 2.7, respectively). The newly proposed Ret-He and %Hypo-He can provide clinicians with information equivalent to CHret and HYPO%.
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| http://dx.doi.org/10.1309/AJCPQAX0JFHFS0OA | DOI Listing |
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