The aim of this study was to investigate the effects of acute, methionine-induced hyperhomocysteinaemia on endothelial function of skin microcirculation in diabetic compared with non-diabetic persons. Endothelial- and non-endothelial-dependent vasodilatation of the skin microcirculation were evaluated in 20 persons with type 2 diabetes (59.95+/-2.36 years old) and 24 age- and gender-matched controls using laser Doppler flowmetry, during fasting and four hours after 0.1 g/kg methionine-induced acute hyperhomocysteinaemia. Methionine loading caused a comparable increase of homocysteine in the two groups. Four hours after induction of acute hyperhomocysteinaemia, endothelial-dependent vasodilatation (acetylcholine effect) was lower in the diabetic patients compared with the controls ([mean+/-SEM] 8.09+/-1.18-fold increase in diabetic patients vs. 11.11+/-1.33-fold increase in controls, p=0.027). The same was observed for the endothelial-independent vasodilatation (sodium-nitroprusside effect, 7.55+/-0.80-fold increase in the diabetic patients vs. 12.19+/-1.26-fold increase in controls, p=0.008). Acute hyperhomocysteinaemia causes a decreased response of both endothelial-dependent and endothelial-independent vasodilatation of the skin microcirculation in diabetic compared with non-diabetic persons. These alterations might contribute to the vascular complications of hyperhomocysteinaemia in diabetes, and especially the microvascular ones.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/1479164110369687 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Givosiran: a targeted treatment for acute intermittent porphyria.
Hematology Am Soc Hematol Educ Program
December 2024
Harvard Medical School, Boston, MA.
The acute hepatic porphyrias (AHPs) are a family of rare genetic diseases associated with attacks of abdominal pain, vomiting, weakness, neuropathy, and other neurovisceral symptoms. Pathogenic variants in 1 of 4 enzymes of heme synthesis are necessary for the development of AHP, and the onset of acute attacks also requires the induction of δ-aminolevulinic acid synthase 1 (ALAS1), the first and rate-limiting step of heme synthesis in the liver. Givosiran is an RNA interference medication that inhibits hepatic ALAS1 and was designed to treat AHP.
View Article and Find Full Text PDFHyperhomocysteinemia Causing Vascular Occlusion and Complicated by Heparin-Induced Thrombocytopenia and Gastrointestinal Bleed.
Cureus
October 2024
General Surgery, Western Reserve Health Education, Northeast Ohio Medical University (NEOMED), Warren, USA.
Homocysteine, an intermediate amino acid, is involved in methionine metabolism, which is crucial for various physiological pathways, including protein synthesis and DNA methylation. Elevated levels of homocysteine have been implicated as both a modifiable and unmodifiable risk factor in cardiovascular disease, influencing atherosclerotic disease formation and hypercoagulability. Mechanisms linking elevated homocysteine levels to vascular occlusion involve endothelial dysfunction, inflammation, and enhanced thrombotic potential.
View Article and Find Full Text PDFPredictive factors for multivessel disease in patients with acute coronary syndrome: analysis from the CCC-ACS project in China.
BMC Cardiovasc Disord
November 2024
National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Northern Theater Command, 83 Wenhua Road, Shenhe District, Shenyang, Liaoning, 110016, China.
Background: Multivessel disease(MVD) is linked to a poorer prognosis, increased complications, longer hospital stays, and higher in-hospital mortality when compared to single-vessel disease(SVD).The purpose of this study is to explore the clinically relevant predictors of acute cornary syndrome (ACS) combined with MVD.
Methods: This multicenter retrospective study included 68,378 ACS patients from 240 hospitals.
Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study.
Cureus
September 2024
Internal Medicine, Gandhi Memorial and Associated Hospitals, King George's Medical University, Lucknow, IND.
Objective Stroke is a leading cause of death and disability globally, with its incidence, prevalence, and mortality rising significantly over the past decades. Beyond traditional risk factors, vitamin B12 has garnered attention for its role in stroke prevention due to its influence on homocysteine metabolism. Deficiencies in vitamin B12 are linked to hyperhomocysteinemia, which increases the risk of ischemic stroke.
View Article and Find Full Text PDFEstablishment of a prediction model for venous thromboembolism in patients with acute exacerbation of chronic obstructive pulmonary disease based on serum homocysteine levels and Wells scores: a retrospective cohort study.
BMC Cardiovasc Disord
October 2024
Department of Emergency, Shenzhen Nanshan People's Hospital, No. 89, Taoyuan Road, Nanshan District, Shenzhen, Guangdong Province, 518052, China.
Background: We evaluated the diagnostic value of homocysteine (Hcy) levels combined with the Wells score and established a prediction model for venous thromboembolism (VTE) occurrence in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) based on the Hcy level and the Wells score.
Patients And Methods: Clinical information from 914 patients with AECOPD was retrospectively collected in our hospital from June 2020 to October 2023. Receiver operating characteristic curves were plotted to evaluate the diagnostic ability of Hcy concentrations combined with Wells scores and the prediction ability of the model.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!