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The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists. | LitMetric
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The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists.

Mark Reid Ian Carlyle Wilson L Caulfield Tom R Clarkson Fiona Cusick Ola Epemolu Robert Gilfillan Richard Goodwin David Jaap Elise C O'Donnell Jeremy Presland Zoran Rankovic Daniel Spinks Gayle Spinks Anne M Thomson Fiona Thomson James Strain Grant Wishart

Bioorg Med Chem Lett

Department of Chemistry, Schering-Plough Research Institute, Newhouse, Lanarkshire, UK.

Published: June 2010

Antagonists of the 5-HT(6) receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as Alzheimer's disease (AD) and schizophrenia. We report herein the identification and SAR around N-(2-aminoalkyl)-1-(arylsulfonyl)indoline-3-carboxamides-a novel chemotype of 5-HT(6) antagonists.

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http://dx.doi.org/10.1016/j.bmcl.2010.04.085DOI Listing

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