According to the Arthritis Foundation, approximately 1.3 million Americans have rheumatoid arthritis (RA), while an estimated 300,000 children are diagnosed with the disease each year. The disease is 2- to 4-times more common in women than in men and is least common in young men. Current practices in the treatment of RA center on the early detection of the various disease manifestations, specifically joint destruction. The goal of early detection is the implementation of disease-modifying drugs before articular destruction and deformity set in. Advancements in medical imaging have led to methods that facilitate earlier detection and beneficial treatment in the course of RA. Because standard radiographic interpretation assists with diagnosis of later-stage arthritis after articular destruction has occurred, magnetic resonance imaging has proven to be the most effective study for early signs of RA. Other imaging modalities such as ultrasonography and contrast-enhanced computed tomography have also been shown to detect early signs of RA. In conjunction with laboratory testing, these imaging modalities are essential for the early detection and subsequent treatment of RA. Pedal imaging is used by most rheumatologists to detect and monitor disease progression, and by most podiatric surgeons to help direct treatment and plan surgical intervention.
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http://dx.doi.org/10.1016/j.cpm.2009.12.009 | DOI Listing |
Med Sci Monit
December 2024
Department of Neurology, HangZhou Third People's Hospital, Hangzhou, Zhejiang, China.
BACKGROUND This study aimed to analyze the risk factors of central nervous system (CNS) infection caused by reactivation of varicella zoster virus (VZV) and provide reference for the prevention and early diagnosis of VZV-associated CNS infection. MATERIAL AND METHODS A prospective study was conducted on 1030 patients with acute herpes zoster (HZ) admitted to our hospital from January 2021 to June 2023. According to clinical manifestations and auxiliary examinations, they were divided into HZ group of 990 patients and VZV-associated CNS infection group of 40 patients.
View Article and Find Full Text PDFSci Rep
December 2024
Hepatobiliary and Pancreatic Medical Treatment Center, People's Hospital of Xinjiang Uygur, Autonomous Region, Tianchi road, Urumqi, 830011, China.
With the advancement of precise hepatobiliary surgery concepts, the diagnostic and therapeutic approaches for hepatic echinococcosis have undergone significant transformations. However, whether these changes have correspondingly improved patient outcomes remains unclear. A retrospective analysis of these changes will provide crucial guidance for the prevention and treatment of hepatic echinococcosis.
View Article and Find Full Text PDFJ Cardiovasc Transl Res
December 2024
Department of Clinical Laboratory, Henan Provincial People's Hospital, Zhengzhou, China.
This study explored the early diagnosis and prognostic value of copeptin in non-ST-segment elevation acute coronary syndrome (NSTE-ACS). 171 patients with chest pain or myocardial ischemia symptoms were enrolled. Patients with NSTE-ACS were further divided into the non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA).
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December 2024
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, JianShe Road 1#, Zhengzhou, 450000, China.
Previous observational studies have suggested at a potential link between migraine, particularly migraine with aura, and the susceptibility to early-onset ischemic stroke. We aimed to investigate the causal effects of genetically determined migraine and its subtypes on the risk of early-onset ischemic stroke using the two-sample Mendelian randomization method. Genetic instrumental variables associated with migraine and its subtypes were acquired from two sources with the largest sample sizes available.
View Article and Find Full Text PDFAnal Bioanal Chem
December 2024
College of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang, 050017, China.
The abnormal expression of acetylcholinesterase (AChE) is linked to the development of various diseases. Accurate determination of AChE activity as well as screening AChE inhibitors (AChEIs) holds paramount importance for early diagnosis and treatment of AChE-related diseases. Herein, a fluorescent and colorimetric dual-channel probe based on gold nanoclusters (AuNCs) and manganese dioxide nanosheets (MnO NSs) was developed.
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