AI Article Synopsis
- Skin aging primarily involves intrinsic aging and photoaging, leading to a significant loss of collagen fibers in the skin.
- Proton pump inhibitors (PPIs), commonly used for conditions like gastroesophageal reflux disease, may worsen skin aging through two main mechanisms: increasing lysosomal pH and suppressing TGFbeta processing, and inhibiting MNK which affects copper transport and lysyl oxidase activity.
- Both mechanisms result in diminished skin health by disrupting processes essential for collagen maintenance and regeneration.
Article Abstract
Skin aging has long been important to human beings and in recent years this field has received tremendous attention by both researchers and the general population. Cutaneous aging includes two distinct phenomena, intrinsic aging and photoaging, and is characterized mainly by the loss of collagen fibers from dermis. Proton pump inhibitors (PPIs) are widely prescribed gastric acid-reducing agents that are usually consumed for long periods in some conditions such as gastroesophageal reflux disease. We suggest that PPIs can accentuate skin aging by two mechanisms. First, through increasing intralysosomal PH, PPIs can suppress transforming growth factor-beta (TGFbeta) processing and consequently decrease its secretion. Second, through inhibiting MNK, a P-type ATPase with steady-state localization at the trans-Golgi network, PPIs can hamper copper transport and consequently curb lysyl oxidase activity.
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| http://dx.doi.org/10.1016/j.arcmed.2010.02.006 | DOI Listing |
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