AI Article Synopsis
- The paper discusses malignant fibrous histiocytoma (MFH) as a rare urinary tract tumor, highlighting its diagnostic features, histological types, and treatment options.
- A review of 29 reported cases reveals that the storiform-fascicular and inflammatory variants are the most common, with poorer outcomes linked to non-myxoid types.
- High recurrence and metastasis rates (50% and 25%, respectively) underscore the need for prompt treatment, with radical cystectomy and additional therapies recommended as the best approach.
Article Abstract
Objectives: Malignant fibrous histiocytoma (MFH) is an uncommon urinary tract tumor. This paper is intended to provide an update on its diagnostic criteria, pathological and immunohistochemical characteristics, histological classification, prognostic factors, and alternative treatments.
Materials And Methods: All published articles on MFH of the urinary bladder have been reviewed and a descriptive study has been done.
Results: Twenty-nine cases of MFH of the bladder have been reported. The most common morphological variants are storiform-fascicular (41%) and inflammatory (36%) MFH. Non-myxoid variants have a poorer prognosis. Stage T3 MFH was found in 72% of cases at the time of diagnosis. MFH local recurrence and distant metastasis rates were 50% and 25% respectively after surgical treatment only.
Conclusions: MFH of the bladder is a tumor with high local and distant recurrence rates and a low survival rate, and therefore requires early and aggressive treatment. Radical cystectomy with lymphadenectomy and adjuvant radiotherapy is considered to be the treatment of choice, eventually associated to chemotherapy.
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