A new internal fixative made form a titanium-nickel (TiNi) alloy having shape memory properties has been investigated and manufactured in cooperation between the Municipal Hospital Ostrava-Fifejdy, Department of Orthopaedic Surgery and the TU of Ostrava, Institute of Materials Engineering. The shape memory TiNi clamps with optimized parameters were designed after systematic study and development of required substructure. Experiments with animals supported the philosophy of the TiNi memory clamps application in small bone surgery. The conclusion drawn from preclinical, clinical, radiological and histological evidence from a total of 64 patients is that our new clamps proved to meet both contemporary theoretical demands and practical needs. Key words: shape memory alloy, small bone fragments osteosynthesis.
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Multiscale Model Simul
January 2024
Applied Mathematics, University of Colorado, Boulder, CO 80309 USA.
The distinct timescales of synaptic plasticity and neural activity dynamics play an important role in the brain's learning and memory systems. Activity-dependent plasticity reshapes neural circuit architecture, determining spontaneous and stimulus-encoding spatiotemporal patterns of neural activity. Neural activity bumps maintain short term memories of continuous parameter values, emerging in spatially organized models with short-range excitation and long-range inhibition.
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Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Oncolytic viruses (OVs) emerge as a promising cancer immunotherapy. However, the temporal impact on tumor cells and the tumor microenvironment, and the nature of anti-tumor immunity post-therapy remain largely unclear. Here we report that CD4 T cells are required for durable tumor control in syngeneic murine models of glioblastoma multiforme after treatment with an oncolytic herpes simplex virus (oHSV) engineered to express IL-12.
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December 2024
Department of Psychology, University of California, Los Angeles, 502 Portola Plaza, Los Angeles, CA, 90095, USA.
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January 2025
Surrey Sleep Research Centre, University of Surrey.
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January 2025
School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, P. R. China.
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