Purpose: To determine the effects of ultra-low dose beta-radiation (ULDBR) on the physical properties of human erythrocyte membranes.
Materials And Methods: To study the structural changes induced by beta-radiation in erythrocyte ghosts, the interactions of fluorescent probes (1-anilino-8-naphthalene sulfonate, pyrene) with the erythrocyte membranes were investigated. The fluorescent responses to the ULDBR were registered after the addition of (14)C-leucine (37-3700 kBq(l(-1)) in the cellular suspension.
Results: The ULDBR induced essential rearrangements of the membrane structure that appear in alterations of membrane spatial organisation, conformation of membrane proteins (structural flexibility, folding-unfolding), modification of surface and deep zones of membranes, lipid-protein interactions, and fluidity of annular lipids.
Conclusions: These findings are evidence that, as previously discovered by us, the reversible effect of ULDBR on the zeta potential of human erythrocytes and the functional state of the membrane signal systems is most likely realised through local structural and dynamic rearrangements of macromolecules in cellular membranes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/09553001003717167 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-performance 2D electronic devices enabled by strong and tough two-dimensional polymer with ultra-low dielectric constant.
Nat Commun
December 2024
Department of Materials Science and NanoEngineering and the Rice Advanced Materials Institute, Rice University, Houston, TX, 77005, USA.
As the feature size of microelectronic circuits is scaling down to nanometer order, the increasing interconnect crosstalk, resistance-capacitance (RC) delay and power consumption can limit the chip performance and reliability. To address these challenges, new low-k dielectric (k < 2) materials need to be developed to replace current silicon dioxide (k = 3.9) or SiCOH, etc.
View Article and Find Full Text PDFBiomarker potential of plasma cell-free DNA for cholangiocarcinoma.
Heliyon
December 2024
Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
Background: To prevent the development of cholangiocarcinoma, an effective screening opisthorchiasis viverrini and/or differential diagnosis of and the cholangiocarcinoma is crucial needed. The level and quality of cfDNA in plasma are being investigated for their potential role as biomarkers in cholangiocarcinoma.
Methods: The study enrolled 43 healthy controls (N), 36 -infected subjects (OV), and 36 cholangiocarcinoma patients (CCA).
An ultra low frequency spike timing dependent plasticity based approach for reducing alcohol drinking.
Sci Rep
December 2024
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA.
Alcohol use disorder (AUD) is a chronic relapsing brain disorder characterized by an impaired ability to stop or control alcohol consumption despite adverse social, occupational, or health consequences. AUD affects nearly one-third of adults at some point during their lives, with an associated cost of approximately $249 billion annually in the U.S.
View Article and Find Full Text PDFHighly Sensitive and Selective SnO-Gr Sensor Photoactivated for Detection of Low NO Concentrations at Room Temperature.
Nanomaterials (Basel)
December 2024
Institute for Physical and Information Technologies (ITEFI-CSIC), 28006 Madrid, Spain.
Chemical nanosensors based on nanoparticles of tin dioxide and graphene-decorated tin dioxide were developed and characterized to detect low NO concentrations. Sensitive layers were prepared by the drop casting method. SEM/EDX analyses have been used to investigate the surface morphology and the elemental composition of the sensors.
View Article and Find Full Text PDFTetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment.
Mar Drugs
November 2024
Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, Fisheries Research Institute of Fujian, National Research and Development Center for Marine Fish Processing, Xiamen 361021, China.
Tetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms. Because of this and the lack of specific antidotes, TTX poisoning is now a major threat to public health.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!