The importance of tryptophan endogenous metabolites kynurenines in the long-term memory and functioning of the signal cascade GluR - LIMK1 - F-actin, mediating the long-term memory trace storage, was demonstrated. The deficit of kynurenines induced by allopurinol (tryptophanoxygenase inhibitor) suppressed the long-term memory, decreased the LIMK1 expression, and paradoxically increased the F-actin content in the honeybee brain. These data agree with the earlier findings in drosophila mutant vermilion (the mutation of tryptophanoxygenase gene).
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