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Mediation of modifiable risk factors in two multidomain dementia prevention trials.
Alzheimers Dement
January 2025
Department of Public and Occupational Health, Amsterdam UMC Location VUMC, Amsterdam, the Netherlands.
Introduction: We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on dementia incidence.
Methods: We pooled data from the multidomain MAPT (Multidomain Alzheimer Preventive Trial; n = 1679, up to 5-year follow-up) and preDIVA trials (Prevention of Dementia by Intensive Vascular Care; n = 3526, up to 12-year follow-up) in adults aged 70+. We used multiple mediation analysis to quantify the role of 2-year changes in body mass index, systolic blood pressure, total cholesterol, and physical activity in the intervention effects on dementia incidence.
Impact of hospital volume on survival in patients with locally advanced colon cancer - A Dutch population-based study.
Colorectal Dis
February 2025
Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.
Aim: Locally advanced colon cancer (LACC) often necessitates complex prognosis-determining treatment. This study investigated the impact of hospital volume on short- and long-term outcomes following surgery for LACC.
Method: Data involving all patients with LACC categorized as clinical T4 and/or N2, between 2015 and 2019 in the Netherlands, were extracted from the Netherlands Cancer Registry.
A Dive Into Yeast's Sugar Diet-Comparing the Metabolic Response of Glucose, Fructose, Sucrose, and Maltose Under Dynamic Feast/Famine Conditions.
Biotechnol Bioeng
January 2025
Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.
Microbes experience dynamic conditions in natural habitats as well as in engineered environments, such as large-scale bioreactors, which exhibit increased mixing times and inhomogeneities. While single perturbations have been studied for several organisms and substrates, the impact of recurring short-term perturbations remains largely unknown. In this study, we investigated the response of Saccharomyces cerevisiae to repetitive gradients of four different sugars: glucose, fructose, sucrose, and maltose.
View Article and Find Full Text PDFExploring Nutrient-Adequate Sustainable Diet Scenarios That Are Plant-Based but Animal-Optimized.
Nutrients
January 2025
Nederlandse Zuivel Organisatie (NZO), 2596 BC The Hague, The Netherlands.
: Transitions toward more sustainable food systems may become rather polarized, particularly in the plant-based vs. animal-based debate. These discussions, however, are often based on environmental impact data from individual products or product groups and do not consider that the products together should form a nutrient-adequate diet that is also affordable.
View Article and Find Full Text PDFScreening for Subclinical Atherosclerosis in Patients with Familial Hypercholesterolemia: Insights and Implications.
J Clin Med
January 2025
Institute of Cardiology, Istanbul University-Cerrahpaşa, 34098 Istanbul, Türkiye.
: Familial hypercholesterolemia (FH) is a monogenic dyslipidemia that leads to early cardiovascular events. Subclinical atherosclerosis refers to the formation of atheromatous plaques in arterial beds before any clinical events. In our study, we investigated the presence, extent, and independent predictors of subclinical atherosclerosis among patients diagnosed with FH.
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