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Pyoderma gangrenosum arising at the site of BCG immunization in a nine-month-old girl.
Immunol Med
December 2024
Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan.
Pyoderma gangrenosum (PG) is an extremely rare disorder in children. We report a nine-month-old girl with PG who presented with high-grade fever and rapidly progressive ulcers at the site of a Bacillus Calmette-Guérin (BCG) inoculation 2 months after the immunization. Additional small pustules developed on her hand and posterior neck three months after the immunization and rapidly progressed.
View Article and Find Full Text PDFLeishmaniasis masquerading as pyoderma gangrenosum in a non-endemic area: A case report.
Australas J Dermatol
November 2024
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.
Pyoderma gangrenosum (PG) can be difficult to diagnose, leading to diagnostic delay which affects patient outcomes and increases health care utilization. Among different scenarios of diagnostic delay, atypical infections can mimic PG. Here, we present a case of extensive cutaneous leishmaniasis initially misdiagnosed as the superficial granulomatous variant of PG and describe diagnostic clues to aid in differentiation.
View Article and Find Full Text PDFClinicopathological Profile of Pyoderma Gangrenosum: A 10-Year Retrospective Study from a Tertiary Care Center in South India.
Indian Dermatol Online J
August 2024
Department of Pathology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Article Synopsis
- Pyoderma gangrenosum (PG) is an inflammatory skin condition that leads to painful, quickly developing ulcers and is often misdiagnosed due to its resemblance to other health issues; this study focused on its clinicopathologic characteristics and underlying conditions among patients in the Indian subcontinent.
- Over a ten-year period, the study identified 17 patients diagnosed with PG, predominantly affecting individuals in their early 30s, with ulcerative variants being most common; nearly a third had systemic associations with autoinflammatory syndromes.
- Treatments typically included systemic steroids and alternative medications, with more than half of the patients achieving remission within 2 to 3 months; however, there were
The Differential Diagnosis of Leg Ulcers.
Dtsch Arztebl Int
November 2024
Department of Dermatology, Venereology and Allergology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Department of Vascular Medicine, Angiology, HELIOS Klinikum Krefeld GmbH, Krefeld, Germany.
Article Synopsis
- Leg ulcers, primarily located below the knee, can stem from various causes with around 80% resulting from chronic venous insufficiency (CVI) or peripheral arterial occlusive disease (PAOD), necessitating diverse medical specialists for treatment.
- The diagnostic approach follows the ABCDE rule, which includes personalized history-taking, bacteriological testing, clinical exams, and additional tests to accurately identify the cause of the ulcer, such as vascular issues or other diseases.
- Effective treatment relies on prompt differential diagnosis, highlighting the need for collaboration among different medical specialties due to the complexity of leg ulcers and the challenges posed by limited high-quality research.
Human Inborn Errors of Immunity in Pyoderma Gangrenosum: A Systematic Review.
Am J Clin Dermatol
September 2024
Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.
Article Synopsis
- Pyoderma gangrenosum (PG) is a rare skin condition linked to immune system issues, but its exact causes are still unclear, prompting a systematic review to explore its connections with inborn errors of immunity.
- A comprehensive literature search revealed 74 cases of PG associated with various genetic mutations, suggesting that PG can occur with a range of immunological deficiencies not typically linked to the disorder.
- Certain genetic mutations, such as those in PSMB8 and NLRP3, are associated with severe cases of PG, while others, like mutations in RAG1 and complement deficiencies, tend to lead to milder symptoms.
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