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A human monoclonal antibody isolated from Japanese encephalitis virus vaccine-vaccinated volunteer neutralizing various flaviviruses.
Front Microbiol
December 2024
School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
Introduction: Japanese encephalitis virus (JEV) and Zika virus (ZIKV) are prevalent in over 80 countries or territories worldwide, causing hundreds of thousands of cases annually. But currently there is a lack of specific antiviral agents and effective vaccines.
Methods: In the present study, to identify human neutralizing monoclonal antibody (mAb) against JEV or/and ZIKV, we isolated ZIKV-E protein-binding B cells from the peripheral venous blood of a healthy volunteer who had received the JEV live-attenuated vaccine and performed 10× Genomics transcriptome sequencing and BCR sequencing analysis, we then obtained the V region amino acid sequences of a novel mAb LZY3412.
The 2023 fatal dengue outbreak in Bangladesh highlights a paradigm shift of geographical distribution of cases.
Epidemiol Infect
January 2025
School of Life Sciences, Faculty of Natural Sciences, Keele University, Keele, Staffordshire, UK.
In 2023, Bangladesh experienced its largest and deadliest outbreak of the Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. Historically, most of the cases were recorded in the capital city, Dhaka. We aimed to characterize the geographical transmission of DENV in Bangladesh.
View Article and Find Full Text PDFA low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure.
PLoS Negl Trop Dis
January 2025
División de Inmunología, Programa de Medicina, Facultad de Ciencias de la Salud, Universidad Surcolombiana, Neiva, Huila, Colombia.
Background: Gestational Zika virus (ZIKV) infection is associated with the development of congenital Zika syndrome (CZS), which includes microcephaly and fetal demise. The magnitude and quality of orthoflavivirus-specific humoral immunity have been previously linked to the development of CZS. However, the role of ZIKV NS1-specific humoral immunity in mothers and children with prenatal ZIKV exposure and CZS remains undefined.
View Article and Find Full Text PDFDengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis.
Open Forum Infect Dis
January 2025
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Article Synopsis
- Dengue virus (DENV) is a significant global health issue, with severe cases potentially worsened by antibodies that can enhance infection rather than neutralize it.
- Researchers are exploring the possibility of targeting DENV-infected cells for immune clearance to avoid antibody-dependent enhancement (ADE).
- This study found that DENV structural proteins are present on infected cell surfaces and can be recognized by immune antibodies, which may facilitate the clearance of infected cells without enriching viral material in certain immune cells.
Cyclopenta[]benzopyran Derivatives and Limonoids from with Cytotoxic and Anti-DENV Activity.
J Nat Prod
January 2025
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Article Synopsis
- Eighteen cyclopenta[]benzopyran derivatives and ten limonoids were discovered, including ten new compounds, identified through advanced analytical techniques.
- Nine of these compounds showed strong cytotoxic effects on cancer cells, with IC values ranging from 3 to 900 nM.
- Sixteen compounds exhibited potent antiviral properties against the dengue virus, with selectivity index values between 13.0 and 532.6, and one compound may act as an eIF4E activator, potentially reducing dengue virus E protein expression.
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