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Microsurgical clipping of blood blister-like anterior communicating artery aneurysm in a patient with total occlusion of left internal carotid artery aneurysm.
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Department of Neurosurgery, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Enoxaparin-Induced Bullous Hemorrhagic Dermatosis and Enoxaparin Rechallenge: A Case Report.
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Boston Medical Center, Boston, MA, USA.
A case of enoxaparin-induced bullous hemorrhagic dermatosis is reported. A 69-year-old male with past medical history including chronic atrial fibrillation and a re-do aortic valve replacement, anticoagulated on warfarin, received an enoxaparin bridge for a molar extraction. On day 7 after restarting enoxaparin post-procedure at a therapeutic dose of 90 mg every 12 hours, the patient noticed multiple small, dark, raised lesions on his forearm and ankle.
View Article and Find Full Text PDFImmune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade.
Nat Commun
December 2024
Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hindering continuous ICI therapy. We examine 6 cohorts including 25 ICI-induced SJS/TEN patients and conduct single-cell RNA sequencing (scRNA-seq) analysis, which shows overexpression of macrophage-derived CXCL10 that recruits CXCR3 cytotoxic T lymphocytes (CTL) in blister cells from ICI-SJS/TEN skin lesions.
View Article and Find Full Text PDFDermatopathological findings of Bothrops atrox snakebites: A case series in the Brazilian Amazon.
PLoS Negl Trop Dis
December 2024
Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas (UEA), Manaus, Brazil.
Article Synopsis
- Bothrops snake venom causes serious local effects like pain, swelling, and bleeding; it's made up mostly of metalloproteinases and phospholipase A2 toxins.
- A study on 22 patients in Manaus highlighted common symptoms such as fang marks, infections, and blistering, along with specific skin changes like spongiosis and hyperkeratosis.
- The findings suggest that both the venom and the body’s inflammatory response contribute to skin damage, indicating a need for improved treatment strategies for snakebite victims.
Nanomaterials-Enabled Sensors for Detecting and Monitoring Chemical Warfare Agents.
Small
December 2024
School of Chemical Engineering, University of New South Wales (UNSW Sydney), Sydney, New South Wales, 2052, Australia.
Despite their restrictions under international treaties, many chemical warfare agents (CWAs) and their toxic analogues are still used in various industrial sectors such as agriculture and chemical manufacturing. Thus, the need for sensitive and selective CWA detection remains critical. Commercially available detection methods, while accurate, are often bulky, expensive, and require specialized personnel.
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