Exertional heat injuries have gained public attention over the past several years, as have the means to prevent and treat them. One of the simplest preventive measures is to refrain from physical training and competition during times of increased environmental heat stress. Unfortunately, this often is not possible or desirable in certain populations. As a result of operational and training requirements, the U.S. Marine Corps and the U.S. Navy medical team have developed an effective exertional heat injury prevention strategy that relies upon education, leadership, and continuous hands-on observation. The fundamental aspects of this approach can be applied to other team sporting activities.
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http://dx.doi.org/10.1249/JSR.0b013e3181df102d | DOI Listing |
BMC Vet Res
December 2024
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Background: High-temperature environment can cause acute kidney injury affecting renal filtration function. To study the mechanism of renal injury caused by heat stress through activates TLR4/NF-κB/NLRP3 signaling pathway by disrupting the filtration barrier in broiler chickens. The temperature of broilers in the TN group was maintained at 23 ± 1 °C, and the HS group temperature was maintained at 35 ± 1℃ from the age of 21 days, and the high temperature was 10 h per day, and one broiler from each replicate group at the age of 35 and 42 days was selected for blood sampling, respectively.
View Article and Find Full Text PDFCell Stress Chaperones
December 2024
Unite postulante de Biologie Genetique, Genomique et Bio-informatique (G2B), Departement de Biologie animale, Faculté des Sciences et Techniques, Universite Cheikh Anta DIOP, Avenue Cheikh Anta DIOP, BP: 5005, Dakar, Senegal. Electronic address:
Malaria caused by Plasmodium spp., is a major public health issue in sub-Saharan Africa. The fight against malaria has stalled due to increasing resistance to treatments and insecticides.
View Article and Find Full Text PDFJ Plant Physiol
December 2024
Federal Scientific Centre of the East Asia Terrestrial Biodiversity of the Far East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia.
Calcium-dependent protein kinases (CDPKs) are very effective calcium signal decoders due to their unique structure, which mediates substrate-specific [Ca] signalling through phosphorylation. However, Ca-dependence makes it challenging to study CDPKs. This work focused on the effects of the overexpression of native and modified forms of the AtCPK1 gene on the tolerance of tobacco plants to heat and cold.
View Article and Find Full Text PDFJ Exp Bot
December 2024
School of Biological Sciences, The University of Western Australia, Perth, WA 6009, Australia.
During their lifespan, plants are often exposed to a broad range of stresses that change their redox balance and lead to accumulation of reactive oxygen species (ROS). The traditional view is that this comes with negative consequences to cells structural integrity and metabolism and, to prevent this, plants evolved a complex and well-coordinated antioxidant defence system that relies on the operation of a range of enzymatic and non-enzymatic antioxidants (AO). Due to the simplicity of measuring their activity, and in the light of the persistent dogma that stress-induced ROS accumulation is detrimental for plants, it is not surprising that enzymatic AO have often been advocated as suitable proxies for stress tolerance, as well as potential targets for improving tolerance traits.
View Article and Find Full Text PDFJ Nanobiotechnology
December 2024
Key Laboratory of Special Environmental Medicine of Xinjiang, General Hospital of Xinjiang Military Command, No. 359, Youhao North Road, Urumqi, Xinjiang, China.
Objective: This study aims to elucidate the mechanisms by which nanovesicles (NVs) transport curcumin(CUR) across the blood-brain barrier to treat hypothalamic neural damage induced by heat stroke by regulating the expression of poly(c)-binding protein 2 (PCBP2).
Methods: Initially, NVs were prepared from macrophages using a continuous extrusion method. Subsequently, CUR was loaded into NVs using sonication, yielding engineered cell membrane Nanovesicles loaded with curcumin (NVs-CUR), which were characterized and subjected to in vitro and in vivo tracking analysis.
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