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This case study explores the psychological and neuropsychological traits of a 55-year-old woman, D.R., who has Cotard's, believing her torso has dissolved and food bypasses her legs.

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Cotard's syndrome before Cotard: A commentary on : Delusions in postpartum psychosis: Implications for cognitive theories.

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Cotard's delusion is a rare and complex condition marked by profound detachment from reality and nihilistic beliefs about decay and mortality, often stemming from underlying psychiatric or neurological issues. In the case of Mr. B, a 44-year-old man with a history of seizure disorder and major depressive disorder (MDD) with psychotic features, his delusions included beliefs that his right leg was decaying and that he was deceased.

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Nihilistic delusions are unique psychopathological experiences characterized by the belief of being deceased, decayed, or obliterated. This case report sheds light on a patient grappling with nihilistic delusions, highlighting the strategies for treating and managing this psychiatric condition. The pathophysiology of Cotard's syndrome remains elusive, with proposed mechanisms being largely speculative.

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The clinical features of neuropsychiatric systemic lupus erythematosus (NPSLE) are heterogeneous. Furthermore, therapeutic decision-making for NPSLE depends on the recognition of clinical syndromes that have not been sufficiently studied. This report describes the case of a 36-year-old woman with NPSLE who exhibited severe cognitive dysfunction and affective psychosis with persistent nihilistic delusions such as those described in the Cotard delusion.

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