During the period from March 4 through 24, 1990 an egg-to-egg cycle of quail incubation on the orbital station Mir was completed. Out of 35 eggs, that developed in space, 8 normal hatchlings emerged, 6 of which were able to get out of the egg-shell without any help. Subsequent observations showed that the hatchlings could not get adapted to the weightless environment or know to remain fixed to the wired floor, due to which they were unable to peck.
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An ancient apical patterning system sets the position of the forebrain in chordates.
Sci Adv
January 2025
Department of Zoology, University of Cambridge, Cambridge, UK.
The evolutionary origin of the vertebrate brain remains a major subject of debate, as its development from a dorsal tubular neuroepithelium is unique to chordates. To shed light on the evolutionary emergence of the vertebrate brain, we compared anterior neuroectoderm development across deuterostome species, using available single-cell datasets from sea urchin, amphioxus, and zebrafish embryos. We identified a conserved gene co-expression module, comparable to the anterior gene regulatory network (aGRN) controlling apical organ development in ambulacrarians, and spatially mapped it by multiplexed in situ hybridization to the developing retina and hypothalamus of chordates.
View Article and Find Full Text PDFExpanded non-invasive prenatal testing offers better detection of fetal copy number variations but not chromosomal aneuploidies.
PLoS One
January 2025
Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe Central Hospital, Luohe, Henan Province, People's Republic of China.
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Methods: Screening results, confirmatory invasive testing results, and follow-up data from pregnant women who underwent either NIPT (6792 cases) or NIPT-Plus (5237 cases) testing at Luohe Central Hospital, China, from January 2019 to June 2023 were collected. The positive predictive value (PPV), sensitivity, specificity, and other indicators for different types of chromosomal abnormalities in NIPT/NIPT-plus screening were calculated.
Aurora B controls microtubule stability to regulate abscission dynamics in stem cells.
Cell Rep
January 2025
Cell Biology, Neurobiology, and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Padualaan, 3584 CS Utrecht, the Netherlands. Electronic address:
Abscission is the last step of cell division. It separates the two sister cells and consists of cutting the cytoplasmic bridge. Abscission is mediated by the ESCRT membrane remodeling machinery, which also triggers the severing of a thick bundle of microtubules.
View Article and Find Full Text PDFEnhanced Transcriptional Activation in Developing Mouse Photoreceptors.
Invest Ophthalmol Vis Sci
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Biology and Biochemistry PhD Programs, Graduate Center, City University of New York, New York, New York, United States.
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View Article and Find Full Text PDFComprehensive Evaluation of Changes in Placentomes in the Second and Third Trimesters of Pregnancy in Cross-Bred Hamdani Sheep.
Vet Med Sci
January 2025
Department of Anatomy, Faculty of Veterinary Medicine, Siirt University, Siirt, Turkey.
Background: A proper placentation is required for establishment and continuity of pregnancy. In sheep, placentomes are unique structures that enable nutrition and gas exchange between the mother and the foetus. Although placentomes are dynamic formations, there is limited knowledge of changes in placentomes during pregnancy.
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