Synthesis of high-purity biogenic heterocyclic library enabled identification of a small molecule, which potently inhibited proliferation of several cancer cell lines and induces rapid oxidative stress. This agent elicited unusual mechanism of cell death induction, which entailed activation of both caspase-dependent and independent pathways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837501 | PMC |
| http://dx.doi.org/10.1002/cbic.201000193 | DOI Listing |
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