Candida is a relatively rare cause of spinal infections that commonly affects immunocompromised patients. A 70-year-old woman, who underwent a lumbar discectomy on L5-S1 two months earlier, was admitted to our department complaining of persistent back and leg pain. Magnetic resonance imaging showed irregular enhancing mass lesion in L5-S1 intervertebral space, suggest of pyogenic discitis with epidural abscess. The surgery was performed via retroperitoneal approach and the infected material at L5-S1 intervertebral space was removed. The histological examination of the specimen revealed chronic inflammation involving the bone and soft tissue, and a culture of the excised material was positive for Candida parapsilosis. The patient received intravenous fluconazole for 4 weeks after surgery and oral fluconazole 400 mg/day for 3 months after surgery. The patient made a full recovery with no symptoms 6 months after surgery. We present a rare case of spondylodiscitis after a lumbar discectomy due to Candida parapsilosis and discuss treatment option with a review of the literatures.
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http://dx.doi.org/10.3340/jkns.2010.47.4.295 | DOI Listing |
Med Mycol
December 2024
Department of Medicine, Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Understanding the impact of different Candida species on patient outcomes is crucial for effective management and treatment strategies. This study aims to comprehensively analyze the association between Candida species and mortality in documented candidemia. We queried TriNetX, a global research network database, to identify patients diagnosed with candidemia through polymerase chain reaction from 2020-2023.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
This study aimed to describe the population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and to identify dosing regimens with a high likelihood of achieving effective exposures. Serial blood samples were collected over a single-dosing interval during ECMO. Total plasma concentrations were measured by a validated chromatographic assay.
View Article and Find Full Text PDFChem Biodivers
December 2024
Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, Pará, Brazil.
Alpinia nutans (L.) Roscoe (Zingiberaceae) is used in folk medicine as an antiviral, anti-inflammatory, and antioxidant. This study aimed to evaluate the seasonality effects on the yield, chemical composition, antioxidant capacity, and anti-Candida activity of the A.
View Article and Find Full Text PDFRes Vet Sci
December 2024
Programa de Pós-Graduação Stricto sensu em Biociência Animal, Universidade de Cuiabá (UNIC), Cuiabá, MT, Brazil.
Companions' animals can present a risk for the transmission of opportunistic diseases to their owners, including those caused by yeasts of the Candida genus residing in their oral microbiota. This study aimed to isolate and identify yeasts from the oral cavity of dogs and assess their susceptibility to antifungals. Yeast species were identified using automated methods MALDI-TOF-MS and VITEK 2 from 50 dogs (aged 2-4 years, various breeds).
View Article and Find Full Text PDFFood Res Int
January 2025
Department of Biology, Federal University of Lavras, Lavras, MG, Brazil. Electronic address:
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