Dr. Catherine Figarella is a world expert in the isolation and characterization of human exocrine pancreatic proteins (enzymatic and non-enzymatic ones). She was a pioneer in the identification and characterization of the numerous zymogens present in pancreatic juice. In particular, her discovery of a peculiar behavior of one of the main proteolytic zymogens: human trypsinogen 1, which was more readily activated into active trypsin than human trypsinogen 2 and trypsinogens of other species led her to propose that a premature intracellular activation of this zymogen may play a role in the pathogenesis of chronic pancreatitis. She demonstrated that a similar phenomenon may occur in cystic fibrosis (CF) and has applied this knowledge of pancreatic zymogens to follow the evolution of the pancreatic disease in CF. With this brief but keen biographical article Dr. Figarella shares her life experience as an innovative medical and biochemical investigator of human exocrine pancreatic function.
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Dr. Catherine Figarella is a world expert in the isolation and characterization of human exocrine pancreatic proteins (enzymatic and non-enzymatic ones). She was a pioneer in the identification and characterization of the numerous zymogens present in pancreatic juice.
View Article and Find Full Text PDFImplication of Reg I in human pancreatic duct-like cells in vivo in the pathological pancreas and in vitro during exocrine dedifferentiation.
Pancreas
July 2004
Groupe de Recherche sur les Glandes Exocrines, Faculté de Médecine, Marseille, France.
A feature associated frequently with the pathologic pancreas is the presence of tubular complexes produced by a phenotypic modulation of acinar cells that take on the characteristics of ductular cells. Since the type I Reg gene, an acinar cell product, is increased in the pancreas following an acinar injury, we aimed to evaluate whether the Reg I protein might be involved in this dedifferentiation process in the human pancreas. We studied duct-like structures in fixed human pathologic pancreatic tissues and human cells with a ductal phenotype obtained by culturing human exocrine preparations.
View Article and Find Full Text PDFUptake of plasmid/glycosylated polymer complexes and gene transfer efficiency in differentiated airway epithelial cells.
J Gene Med
January 2003
Laboratoire de Physiologie Respiratoire, CHU Cochin, AP-HP-Université Paris V, Paris, France.
Background: We have studied gene transfer efficiency of glycosylated polylysines and glycosylated polyethylenimines as vectors in immortalized differentiated airway gland serous cells and primary cultures of human airway surface epithelial cells.
Methods And Results: In both cell types, lactosylated PEI was more efficient for gene transfer than unsubstituted PEI and lactosylated polylysine which requires the presence of endosomolytic agents. However, for all the vectors tested, gene transfer efficiency was lower in differentiated cells as compared with poorly differentiated cells.
Mechanism of restriction of normal and cystic fibrosis transmembrane conductance regulator-deficient human tracheal gland cells to adenovirus infection and ad-mediated gene transfer.
Am J Respir Cell Mol Biol
November 2002
Laboratoire de Virologie et Pathogénèse Virale, Faculté de Médecine RTH Laennec, Lyon, France.
CF-KM4 (cystic fibrosis transmebrane conductance regulator-deficient) and MM-39 (healthy) cells, two serous cell lines from submucosal tracheal glands, were found to be poorly susceptible to adenovirus (Ad)5 infection and Ad5-mediated gene transduction. The major limiting steps apparently resided in the primary events of Ad5 interaction, i.e.
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