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Survival after aluminum phosphide poisoning with cardiotoxicity: a case report.
J Med Case Rep
December 2024
Department of Internal Medicine, Woldia Comprehensive Specialized Hospital, Woldia, Ethiopia.
Introduction: Aluminum phosphide is a cheap and commonly used rodenticide that is also an effective solid fumigant and frequently used for grain preservation. The pill contains around 44% inert elements (ammonium carbonate) to avoid disintegration of the tablet, while the rest (about 56%) is aluminum phosphide. Because it is freely available on the market, it is one of the commonly used agents for self-poisoning in different parts of the developing world.
View Article and Find Full Text PDFEstrogen administration enhances the adverse effects of cigarette smoking on the heart in cycling female mice.
Biol Sex Differ
December 2024
Department of Pharmacology and Toxicology, American University of Beirut Faculty of Medicine, American University of Beirut & Medical Center, Riad El-Solh, Beirut, 11072020, Lebanon.
Article Synopsis
- - Smoking, especially chronic smoking, poses a significant health risk by increasing the chances of heart-related diseases and causing damage to the heart's structure and function through oxidative stress and endothelial dysfunction.
- - This study examines how chronic cigarette smoke interacts with the oral contraceptive ethinylestradiol in premenopausal females, revealing that their combination leads to negative changes in heart structure, such as larger left ventricular size and increased heart mass.
- - Results indicate that this combination triggers an inflammatory response, with elevated inflammatory markers and collagen deposition, suggesting it may lead to heart conditions similar to dilated cardiomyopathy.
Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafish.
bioRxiv
November 2024
Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Venous thrombosis is a well-known complication of sex hormone therapy, with onset typically within weeks to months after initiation. Worldwide, more than 100 million pre-menopausal women use combined oral contraceptives, with tens to hundreds of thousands developing thrombosis annually, resulting in significant morbidity and mortality. Although it is known that estrogens can alter expression of coagulation factors, the pathways and mechanisms that connect the two systems, as well as the proteins involved in progression to thrombosis, are poorly understood.
View Article and Find Full Text PDFRisk factors for ectopic pregnancy occurrence: Systematic review and meta-analysis.
Int J Gynaecol Obstet
November 2024
Bahiana School of Medicine and Public Health, Salvador, Brazil.
Article Synopsis
- The study addresses the critical issue of ectopic pregnancy (EP) and its associated health risks, emphasizing the need to identify risk factors for better care and early diagnosis.
- A systematic review and meta-analysis were conducted, analyzing studies published in English and Portuguese, and focusing on various predisposing factors for EP.
- Results indicated strong associations between EP and factors such as previous EP history, pelvic inflammatory disease, infertility, and past abdominal or pelvic surgeries, highlighting areas for increased awareness and prevention strategies.
Venous thromboembolism is a multifactorial dis ease and major cause of morbidity and mortality. Absolute risk of venous thromboembolism is less than 1 per 10,000 per year in women of reproductive age. Hormonal contraception is a common risk situation for venous thromboembolism in this part of the population.
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