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Top-down curing to construct self-retaining and moisture-pumping double-layered dressing with enhanced antibacterial, hemostatic, and wound healing performances.
Nanoscale
January 2025
Analytical & Testing Center; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610064, China.
Continuous microenvironment modulation is an ongoing challenge in wound dressing, which includes excessive exudate absorption, oxygen delivery, bacterial inhibition and angiogenesis. Herein, we developed an construction strategy to fabricate a self-retaining double-layered wound dressing, where the top layer precursor was composed of Ca-containing polyvinyl butyral (PVB) solution dispersed with hydroxypropyl methylcellulose (HPMC) particles, and the bottom one consisted of sodium alginate (Alg) solution blended with Ag-doped mesoporous bioactive glass powders (Ag-MBG). When in use, both precursors were simultaneously squeezed out from the twin nozzles connected to the individual chambers of a twin-chambered syringe, whereby Ca in the top layer rapidly migrated downwards to crosslink Alg in the bottom layer, leading to the formation of an Alg/Ag-MBG (AA) functional hydrogel for filling an irregular wound.
View Article and Find Full Text PDFBlue Electroluminescent Carbon Dots Derived from Victorian Lignite.
ACS Omega
January 2025
Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama 236-0027, Japan.
Carbon dots (CDs) derived from natural products have attracted considerable interest as eco-friendly materials with a wide range of applications, such as bioimaging, sensors, catalysis, and solar energy harvesting. Among these applications, electroluminescence (EL) is particularly desirable for light-emitting devices in display and lighting technologies. Typically, EL devices incorporating CDs feature a layered structure, where CDs function as the central emissive layer, flanked by charge transport layers and electrodes.
View Article and Find Full Text PDFAn alternatively translated isoform of PPARG proposes AF-1 domain inhibition as an insulin sensitization target.
Diabetes
January 2025
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
PPARγ is the pharmacological target of thiazolidinediones (TZDs), potent insulin sensitizers that prevent metabolic disease morbidity but are accompanied by side effects such as weight gain, in part due to non-physiological transcriptional agonism. Using high throughput genome engineering, we targeted nonsense mutations to every exon of PPARG, finding an ATG in Exon 2 (chr3:12381414, CCDS2609 c.A403) that functions as an alternative translational start site.
View Article and Find Full Text PDFSpray-Printed Light-Emitting Diodes with Perovskite/Polymer Composite Emitters on Various Transparent Substrates.
ACS Appl Mater Interfaces
January 2025
Department of Chemical and Biological Engineering, Sookmyung Women's University, Seoul 04310, Korea.
Advancements in printing techniques are essential for fabricating next-generation displays. Lead halide perovskites demonstrate great potential as light emitters of solution-processed light-emitting diodes (LEDs). In particular, the perovskite/polymer composite emitters exhibit exceptional luminescent characteristics, mechanical flexibility, and environmental stability due to the improved film morphologies and defect passivation achieved through the introduction of polymer additives.
View Article and Find Full Text PDFToughening of thermoset composites using glass/polypropylene commingled stitching yarns.
Heliyon
January 2025
Portsmouth Centre for Advanced Materials and Manufacturing (PCAMM), School of Electrical and Mechanical Engineering, University of Portsmouth, Portsmouth, PO1 3DJ, UK.
This paper investigates the damage resistance and tolerance of thermoset composite laminates stitched by glass and hybrid glass/polypropylene commingled yarns. Different impact energies (10-70 J) were applied to stitched composite laminates before compression after impact (CAI) tests were conducted. The results showed that, except for 70J, commingled yarn-stitched laminates absorbed more energy than glass-stitched laminates.
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