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Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs.
J Cell Biol
February 2025
Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Endocytosis, required for the uptake of receptors and their ligands, can also introduce pathological aggregates such as α-synuclein (α-syn) in Parkinson's Disease. We show here the unexpected presence of intrinsically perforated endolysosomes in neurons, suggesting involvement in the genesis of toxic α-syn aggregates induced by internalized preformed fibrils (PFFs). Aggregation of endogenous α-syn in late endosomes and lysosomes of human iPSC-derived neurons (iNs), seeded by internalized α-syn PFFs, caused the death of the iNs but not of the parental iPSCs and non-neuronal cells.
View Article and Find Full Text PDFEnterococcus hirae Bacteremia Associated With Traumatic Soft Tissue Infection: A Case Report.
Cureus
November 2024
Department of Intensive Care Medicine, Centro Hospitalar Universitário de São João, Porto, PRT.
In recent years, reports of infections in humans have increased. Similarly to most known Enterococci, has been identified mostly in bacteremia, urinary tract infections, infective endocarditis, and biliary tract infections. We present a case of bacteriemia associated with traumatic soft tissue infection in a 77-year-old male patient, a polytrauma victim with a tibia-fibula open fracture after a forklift accident.
View Article and Find Full Text PDFAcquired methemoglobinemia in infancy secondary to diarrhea: a case report.
Pan Afr Med J
December 2024
Al Jalila Children's Hospital, Dubai Health, Dubai, United Arab Emirates.
Methemoglobinemia (MetHb) is a life-threatening condition that reduces the oxygen-carrying ability of hemoglobin. Acquired methemoglobinemia usually results from exposure to specific oxidizing agents. Symptoms and complications depend on the MetHb level, which can sometimes be fatal.
View Article and Find Full Text PDFTrends in tuberculosis and inequality-adjusted Human Development Index in Brazil, 2018-2022.
J Public Health Policy
December 2024
Department of Pathology, FMUSP, Av. Dr. Enéas de Carvalho Aguiar, 470, São Paulo, Brazil.
Tuberculosis (TB) remains a significant global health concern, causing 1.5 million deaths annually. We conducted an ecological analysis to examine TB prevalence in Brazil from 2018 to 2022, focusing on its relationship with the Human Development Index (HDI) and its inequality-adjusted version HDI (IHDI).
View Article and Find Full Text PDFDelivering the News of an Intraoperative Death; Literature Based Guidance from the AATS Wellness Committee.
J Thorac Cardiovasc Surg
December 2024
Norton Thoracic Institute, Dignity Health, Phoenix, Arizona (nothing to disclose).
Objectives: Fortunately, operating room deaths and unexpected deaths are infrequent occurrences. However, when they occur, the surgeon is called upon to deliver this news to family and loved ones. There is a paucity of literature on this topic and little guidance preparing cardiothoracic surgeons for this important but difficult situation.
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