Haplotype and allele frequencies of 17 Y-chromosomal short tandem repeat (Y-STR) markers in a population sample of 133 Yakut male volunteers from two regions: Central (n=41) and Western Yakutia (n=92) were determined using the AmpFlSTR Yfiler PCR Amplification Kit (Applied Biosystems). A total of 65 haplotypes were identified in the Yakut population, with 15 haplotypes in Central sample and 54 haplotypes in Western sample. Haplotype diversity values of 0.79 and 0.96, and average gene diversity values of 0.14 and 0.41 were calculated for Central and Western samples, respectively. The Fst distances between both our Yakut populations with other Russian, Siberian and Chinese populations were represented by MDS plot. The graphical view demonstrated close distances between most Yakut populations and differences with other Siberian populations.
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http://dx.doi.org/10.1016/j.fsigen.2010.01.018 | DOI Listing |
Nat Prod Res
January 2025
Department of Applied Science, Faculty of Engineering & Technology, Gurukula Kangri (Deemed to be University), Haridwar, India.
The present study aimed to evaluate the nutrition value, phytochemical content, and diverse pharmacological activities of different solvent extracts of L. fruit. Among all, the hydro-alcoholic extract showed high DPPH and ABTS radical scavenging activities with IC values of 82.
View Article and Find Full Text PDFGene Ther
January 2025
Shanghai Bao Pharmaceuticals Co., Ltd., No. 28 Luoxin Road, Baoshan, Shanghai, China.
The approved intravenous adeno-associated virus (AAV) therapies are limited by the widespread prevalence of pre-existing anti-AAV antibodies in the general population, which are known to restrict patients' ability to receive gene therapy and limit transfection efficacy in vivo. To address this challenge, we have developed a novel recombinant human immunoglobulin G degrading enzyme KJ103, characterized by low immunogenicity and clinical value for the elimination of anti-AAV antibodies in gene transfer. Herein, we conducted two randomized, blinded, placebo-controlled, single ascending dose Phase I studies in China and New Zealand, to evaluate the pharmacokinetics, pharmacodynamics, safety and immunogenicity of KJ103 in healthy volunteers.
View Article and Find Full Text PDFSci Rep
January 2025
Computer Science Department, Faculty of Computers and Information, South Valley University, Qena, 83523, Egypt.
Adversarial attacks were commonly considered in computer vision (CV), but their effect on network security apps rests in the field of open investigation. As IoT, AI, and 5G endure to unite and understand the potential of Industry 4.0, security events and incidents on IoT systems have been enlarged.
View Article and Find Full Text PDFSci Total Environ
January 2025
Guangzhou Huadu district drainage management center, Guangzhou 510800, China.
Rapid urbanization has significantly altered surface landscape configurations, leading to complex urban climates. While much attention has been focused on impervious surfaces' impact on extreme precipitation, a critical gap remains in understanding how various 2D urban landscape components influence extreme precipitation across different durations. Through an analysis of the non-stationarity and spatiotemporal variations in extreme precipitation across the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) from 1990 to 2020, we constructed the non-stationary Generalized Additive Models for Location Scale and Shape (GAMLSS) model by introducing six urban landscape structural metrics as explanatory variables for each of the 27 meteorological stations in the GBA.
View Article and Find Full Text PDFSchizophr Res
January 2025
Dell Medical School, The University of Texas at Austin, United States; Department of Psychiatry, Indiana University School of Medicine, United States.
Learning Health Systems (LHSs) promise meaningful health care improvement through the ongoing use of data, including the lived experience of diverse constituents, such as people participating in and providing services. Most LHSs operate within a specific healthcare system, typically hospital-based, under a common electronic health record (EHR) and management structure. The Early Psychosis Intervention Network in Texas (EPINET-TX) is a novel case study of a developing LHS across 16 independent community mental health clinics operating state-funded coordinated specialty care (CSC) programs for early psychosis.
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