A 58-year-old man presented at the dermatology outpatient clinic with a subcutaneous nodule on his left hand. The patient could not recall a previous injury. Excision revealed an epithelioid hemangioendothelioma, a rare and malignant vascular tumour, characterized by slow progression and often located on the upper and lower extremities. The patient was referred to a specialist group for soft-tissue tumours. He underwent excision, after which the wound was closed using a non-invasive adhesive wound closure. Since the excision was not very extensive, supplementary radiotherapy was given. Four years later there was no relapse or occurrence of metastases. Invasive investigation of a soft-tissue tumour, such as skin biopsy or diagnostic excision, may interfere with potential MRI - the diagnostic imaging tool indicated in the guidelines. However, a soft-tissue tumour is often only suspected at the last moment. When a soft-tissue tumour is suspected, the doctor should refer the patient to one of the specialist groups for soft-tissue tumours for further diagnosis and therapy.
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Echocardiography
January 2025
Department of Hospitalization, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico.
A 43-year-old woman presented with dyspnea and cough, initially misdiagnosed as respiratory syncytial virus. Persistent symptoms led to pulmonary thromboembolism treatment, but worsening issues revealed recurrent pericardial effusion. Imaging and biopsy confirmed pulmonary artery intimal sarcoma, mimicking thromboembolism, and autoimmune disease, underscoring diagnostic challenges.
View Article and Find Full Text PDFNoncoding RNA Res
April 2025
China-ASEAN College of Marine Sciences, Xiamen University Malaysia, 43900, Sepang, Selangor, Malaysia.
Liposarcoma is one of the most prevalent forms of soft tissue sarcoma, and its prognosis is highly dependent on its molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) can bind various cellular targets to regulate carcinogenesis. By affecting the expressions and activities of their downstream targets post-transcriptionally, dysregulations of miRNAs can alter different oncogenic signalling pathways, mediating liposarcoma progression.
View Article and Find Full Text PDFBMC Cancer
December 2024
Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Background: Soft-tissue sarcomas are rare tumors of the soft tissue. Recent diagnostic studies mainly dealt with conventional image analysis and included only a few cases. This study investigated whether low- and high-proliferative soft tissue sarcomas can be differentiated using conventional imaging and radiomics features on MRI.
View Article and Find Full Text PDFJ West Afr Coll Surg
July 2024
National Ear Care Centre, Kaduna, Nigeria.
Sinonasal leiomyoma is an exceptionally rare neoplasm arising from smooth muscle cells within the sinonasal tract. This abstract presents a case study of a 43-year-old male patient diagnosed with sinonasal leiomyoma, a distinctive and challenging entity in otolaryngology. The patient presented with a complex clinical history, including a 2-year interval between initial evaluation and definitive diagnosis.
View Article and Find Full Text PDFAm J Case Rep
December 2024
Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
BACKGROUND Limb-girdle muscular dystrophy recessive 1 (LGMDR1) is an autosomal recessive degenerative muscle disorder characterized by progressive muscular weakness caused by pathogenic variants in the CAPN3 gene. Desmoplastic small round cell tumors (DSRCT) are ultra-rare and aggressive soft tissue sarcomas usually in the abdominal cavity, molecularly characterized by the presence of a EWSR1::WT1 fusion transcript. Mouse models of muscular dystrophy, including LGMDR1, present an increased risk of soft tissue sarcomas.
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