AI Article Synopsis
- The study examined the neurophysiological differences in olfactory processing between individuals with schizophrenia and healthy controls using a 30-channel EEG during hydrogen sulfide detection.
- Both groups had similar detection rates for high and low odor concentrations, and their ERP waveforms were alike.
- However, patients exhibited significantly reduced brain activity (N1 sink and P2 source) in response to high-intensity odors, indicating a specific olfactory dysfunction associated with schizophrenia.
Article Abstract
To better characterize neurophysiologic processes underlying olfactory dysfunction in schizophrenia, nose-referenced 30-channel electroencephalogram was recorded from 32 patients and 35 healthy adults (18 and 18 male) during detection of hydrogen sulfide (constant-flow olfactometer, 200 ms unirhinal exposure). Event-related potentials (ERPs) were transformed to reference-free current source density (CSD) waveforms and analyzed by unrestricted Varimax-PCA. Participants indicated when they perceived a high (10 ppm) or low (50% dilution) odor concentration. Patients and controls did not differ in detection of high (23% misses) and low (43%) intensities and also had similar olfactory ERP waveforms. CSDs showed a greater bilateral frontotemporal N1 sink (305 ms) and mid-parietal P2 source (630 ms) for high than low intensities. N1 sink and P2 source were markedly reduced in patients for high intensity stimuli, providing further neurophysiological evidence of olfactory dysfunction in schizophrenia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341093 | PMC |
| http://dx.doi.org/10.1111/j.1469-8986.2010.01013.x | DOI Listing |
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