AI Article Synopsis
- The study investigates how diabetes affects salivary glands by examining biopsies from both diabetic and non-diabetic patients using electron microscopy.
- Findings reveal that diabetic patients show increased secretory granules and changes in granule structure, with type 1 diabetes resulting in higher levels of amylase expression compared to non-diabetic individuals.
- The research concludes that diabetes causes distinct changes in salivary gland secretory protein expression, potentially leading to oral health issues common in individuals with diabetes.
Article Abstract
Background: Salivary dysfunction and oral disorders have been described in both type 1 and type 2 diabetes mellitus. However, the cellular and molecular consequences of diabetes on oral tissues remain to be ascertained. The purpose of this investigation was to study, by means of electron microscopy, the morphologic and molecular changes that occur in salivary glands during diabetes.
Methods: Biopsy samples of parotid glands were excised from non-diabetic and diabetic (type 1 and type 2) consenting patients and processed by standard methods for routine morphology and electron microscopic immunogold labeling. Specific antibodies were used to determine and quantify the expression of secretory proteins (alphaamylase and the regulatory subunit of type II protein kinase A).
Results: Morphologic changes in the diabetic samples included increased numbers of secretory granules, and alterations in internal granule structure. Quantitative analysis of immunogold labeling showed that labeling densities were variable among the parotid gland samples. In type 1 diabetes amylase expression was greater than in non-diabetic glands, whereas in type 2 diabetes it was not significantly changed. Expression of type II regulatory subunits was slightly, although not significantly, increased in acinar secretory granules of type 1 diabetic samples and was unchanged in type 2 diabetic samples.
Conclusions: Our data show that diabetes elicits specific changes in secretory protein expression in human salivary glands, thus contributing to the altered oral environment and oral disease associated with diabetes.
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| http://dx.doi.org/10.1111/j.1600-0714.2010.00898.x | DOI Listing |
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