The gammadelta T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because gammadelta T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that gammadelta T cell subsets also appear to be biased to carry out particular functions. This suggests that particular gammadelta TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined gammadelta T cell subsets, and evidence that their functions are predetermined in the thymus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906689 | PMC |
| http://dx.doi.org/10.1016/j.smim.2010.03.006 | DOI Listing |
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