Clear cell tumor of the lung: surgical and immunohistochemical findings.

Gen Thorac Cardiovasc Surg

Department of Chest Surgery, Matsudo City Hospital, 4005 Kamihongo, Matsudo, Chiba, 271-8511, Japan.

Published: May 2010

AI Article Synopsis

  • A clear cell tumor of the lung (CCTL) was found in a 65-year-old woman during a routine chest exam, leading to wedge resection surgery.
  • The tumor was visible during surgery and changed color from red to white when clamped, indicating its unique characteristics.
  • Pathological analysis showed large clear cells without unusual features, and the tumor was diagnosed as benign after ruling out similar findings in the kidneys.

Article Abstract

We encountered a clear cell tumor of the lung (CCTL) that was located peripherally, adjacent to the visceral pleura. The tumor could be directly observed during surgery. We believe that this case report describing the surgical and related pathological findings is highly informative. A chest radiograph during routine examination of an asymptomatic 65-year-old woman being treated for hypertension and hyperlipidemia revealed a nodular shadow in the left lung field. Wedge resection was performed by video-assisted thoracic surgery. The in vivo color of the tumor was red, suddenly changing to white after the tumor was clamped. Pathology examination showed a uniform pattern consisting of large clear cells without cytologic atypia or increased mitotic activity. Immunohistochemistry revealed tumor cells positive for vimentin and melanocytic markers (HMB-45 and melan-A) and negative for epithelial membrane antigen and cytokeratin. With the absence of clinical findings in both kidneys, the tumor was diagnosed as a benign CCTL.

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http://dx.doi.org/10.1007/s11748-009-0513-2DOI Listing

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