AI Article Synopsis
- Click reactions are a select group of chemical reactions known for their efficiency, compatibility with solvents, and high yields, making them useful in various fields.
- Among these, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes is particularly notable for its applications in chemical biology and proteomics.
- The survey highlights the role of click chemistry in catalomics, specifically in areas like activity-based protein profiling (ABPP), posttranslational modifications (PTMs), and the development of enzyme inhibitors.
Article Abstract
Of the thousands of known chemical reactions, a handful of reactions, called "click" reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.
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