A review of a series of epileptic patients revealed the importance of the 'lost time' in the future time course of a patient. The 'lost time' is regarded as the period of time elapsed since the onset of symptoms and the implementation of adequate treatment. An assessment of the follow-up of 3,529 epileptic patients showed that the shorter the 'lost time', the greater the efficacy of anticonvulsant treatment. Even the incidence of relapses after discontinuation of antiepileptic drugs correlates with the 'lost time' before diagnosis. These findings emphasize the importance of establishing an early diagnosis of the type of epilepsy and the prescription of adequate antiepileptic medication.
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http://dx.doi.org/10.1159/000116672 | DOI Listing |
PLoS One
January 2025
School of Computer Science and Engineering, Changchun University of Technology, Changchun, Jilin, China.
Parkinson's disease (PD) is a common disease of the elderly. Given the easy accessibility of handwriting samples, many researchers have proposed handwriting-based detection methods for Parkinson's disease. Extracting more discriminative features from handwriting is an important step.
View Article and Find Full Text PDFClin Orthop Relat Res
January 2025
Department of Rehabilitation, Radboud University Medical Center, Nijmegen, the Netherlands.
Background: Many patients with a lower limb socket-suspended prothesis experience socket-related problems, such as pain, chronic skin conditions, and mechanical problems, and as a result, health-related quality of life (HRQoL) is often negatively affected. A bone-anchored prosthesis can overcome these problems and improve HRQoL, but these prostheses have potential downsides as well. A valid and reliable tool to assess potential candidates for surgery concerning a favorable risk-benefit ratio between potential complications related to bone-anchored prostheses and improvements in HRQoL is not available yet.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología, Biotecnología y Genética, Universidad de Buenos Aires, Buenos Aires, Argentina.
Introduction: Polycystic Ovary Syndrome (PCOS) affects 5-20% of reproductive-aged women. Insulin resistance (IR) is common in PCOS with consequent elevated risks of metabolic disorders and cardiovascular mortality. PCOS and obesity are complex conditions associated with Metabolic Syndrome (MS), contributing to cardiovascular disease and type 2 diabetes mellitus (T2D).
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address:
During the application of most conventional pesticides, a significant proportion is lost through rain wash-off and leaf rolling, leading to reduced actual utilization efficiency. In this paper, aminated dendritic mesoporous organosilicon nanoparticles (DMONs-NH) were synthesized via a one-pot method and used as carriers. Carbendazim (CBZ) was then encapsulated within DMONs-NH through hydrogen bonding and electrostatic interactions.
View Article and Find Full Text PDFBurns
December 2024
School of Public Health and Preventive Medicine, Monash University, Australia; Population Data Science, Swansea University, Wales.
Background: A better understanding of how major burns patients recover following injury is vital in assessing trauma care and informing healthcare and rehabilitation provision. We aimed to describe the longer-term health and return to work status of major burns patients and identify factors associated with positive outcomes i.e.
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