Objectives: To evaluate the role of genetic background in osteoporosis/osteopenia development in beta-Thalassemia Major patients.
Design And Methods: The influence of VDR (FokI, BsmI) as well as COLIA1 (Sp1) gene polymorphisms on BMD was investigated in 40 patients.
Results: Although the examined gene polymorphisms did not significantly affect BMD variations in our population, BsmI was found to display beneficial effects on patient response to alendronate therapy.
Conclusion: Genetic factors retain a potential role for improvement of osteoporosis management in thalassemic patients.
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| http://dx.doi.org/10.1016/j.clinbiochem.2010.04.070 | DOI Listing |
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