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Article Synopsis
  • The Indian Coffee Plum (Flacourtia jangomas) is a medicinal plant known for its bioactive compounds and potential therapeutic benefits, prompting research into its extracts from bark for medical applications.
  • The study involved extracting phytochemicals using methanol, conducting screenings, and comparing the biological activities of the extracts, revealing the presence of new compounds like methyl caffeate and flacourtin.
  • Results showed the extract has strong antioxidant and cytotoxic properties, pain relief effects, and moderate thrombolytic action, but limited antibacterial and antifungal activities, indicating a need for further research on its bioactive compounds.
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In tropical nations, snakebite envenomation is a significant public health issue with negative human and social effects. This is due to three factors: 1) more species of the most hazardous snakes are present; 2) emergency medical assistance is not readily available; and 3) inadequate health care. The problems caused by snakebite envenomation have been partially resolved by immunotherapy.

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Introduction: The pulmonary Hot Clot artifact (HCa) on 18F-FDG PET/CT is a poorly understood phenomenon, corresponding to the presence of a focal tracer uptake without anatomical lesion on combined CTscan. The hypothesis proposed in the literature is of microembolic origin. Our objectives were to determine the incidence of HCa, to analyze its characteristics and to identify associated factors.

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Hot under the clot: venous thrombogenesis is an inflammatory process.

Blood

August 2024

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

Venous thrombosis (VT) is a serious medical condition in which a blood clot forms in deep veins, often causing limb swelling and pain. Current antithrombotic therapies carry significant bleeding risks resulting from targeting essential coagulation factors. Recent advances in this field have revealed that the cross talk between the innate immune system and coagulation cascade is a key driver of VT pathogenesis, offering new opportunities for potential therapeutic interventions without inducing bleeding complications.

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To clot, or not to clot: The dilemma of hormone treatment options for menopause.

Thromb Res

October 2022

Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa. Electronic address:

Untreated menopause may have serious health implications, but treatments can have dangerous side effects. We evaluate menopausal symptoms as well as available treatments -the routes of administration and their effect on blood coagulation. Menopausal females may experience hot flushes, vulva- and vaginal atrophy and osteoporosis.

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