BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca(2+). Here, we report sequence-specific (1)H, (13)C, and (15)N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.
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1H, 13C and 15N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy.
Biomol NMR Assign
October 2010
Structural and Computational Biology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India.
BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca(2+). Here, we report sequence-specific (1)H, (13)C, and (15)N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.
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