CRACR2A is a newly discovered Ca-binding protein that regulates store-operated Ca entry (SOCE). CRACR2A enhances SOCE by promoting the binding of the endoplasmic reticulum Ca sensor STIM to Orai, a Ca channel located in the plasma membrane. As intracellular Ca levels rise, CRACR2A binds Ca and triggers SOCE inactivation by dissociating from the Orai–STIM complex.
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| http://dx.doi.org/10.1038/ncb0510-416 | DOI Listing |
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