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Recombinant elastin-mimetic biomaterials: Emerging applications in medicine. | LitMetric

Recombinant elastin-mimetic biomaterials: Emerging applications in medicine.

Adv Drug Deliv Rev

Department of Biomedical Engineering, Emory University/Georgia Institute of Technology, Atlanta, 30332, USA.

Published: December 2010

AI Article Synopsis

  • Biomaterials made from protein-based block copolymers, especially recombinant elastin, are being studied for medical uses.
  • These elastin block copolymers can be shaped into various forms like particles, films, gels, and fibers, allowing for tailored biological and mechanical properties.
  • The review focuses on the synthesis of elastin-mimetic triblock copolymers and their processing methods for medical applications.

Article Abstract

Biomaterials derived from protein-based block copolymers are increasingly investigated for potential application in medicine. In particular, recombinant elastin block copolymers provide significant opportunities to modulate material microstructure and can be processed in various forms, including particles, films, gels, and fiber networks. As a consequence, biological and mechanical responses of elastin-based biomaterials are tunable through precise control of block size and amino acid sequence. In this review, the synthesis of a set of elastin-mimetic triblock copolymers and their diverse processing methods for generating material platforms currently applied in medicine will be discussed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937194PMC
http://dx.doi.org/10.1016/j.addr.2010.04.007DOI Listing

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