Background: Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)-recommended case definitions for MHF.
Methods: Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity.
Results: A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our data-derived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions.
Conclusions: Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407405 | PMC |
| http://dx.doi.org/10.1086/652748 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Common Diagnostic Dilemma: Inflammation or Infarction.
JACC Case Rep
January 2025
Cardiovascular Institute, Carilion Clinic, Virginia Tech Carilion School of Medicine, Roanoke, Virginia USA.
Early infarct-associated pericarditis is a rare entity, given the availability of early coronary angiography and intervention. Although the electrocardiogram and the surface echocardiogram are initial studies, definitive imaging with cardiac magnetic resonance is recommended. We present a case of early infarct-associated pericarditis in the setting of a late-presenting silent right coronary artery myocardial infarction.
View Article and Find Full Text PDFExtratesticular intrascrotal epidermoid cysts presenting like polyorchidism: a case report.
Pan Afr Med J
January 2025
Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Bilateral scrotal masses may present as polyorchidism or benign neoplasms. Epidermoid cysts (ECs) are common benign cutaneous lesions that are characterized by encapsulated sebaceous cysts containing keratin. These cysts can undergo complications such as ruptures, infections, or daughter cyst formation.
View Article and Find Full Text PDFFeminist debates on how the state incorporates and reshapes feminist categories of violence reveal unintended consequences, such as the depoliticization of these ideas. Through a case study of the Feminicídio Law in Brazil, I examine feminist writings on , following its state incorporation as a criminal category, to address the killing of women based on gendered reasons. Drawing on materialist feminist discourse analysis, I challenge the notion that institutionalization necessarily leads to depoliticization.
View Article and Find Full Text PDFFistula in Crohn's disease: classification, pathogenesis, and treatment options.
Tissue Barriers
January 2025
Department of Gastroenterology and Hepatology, Virginia Tech Carilion School of Medicine (VTCSOM), Carilion Clinic, Roanoke, VA, USA.
Crohn's disease is a form of inflammation that affects the gastrointestinal (GI) tract. It is characterized by persistent inflammation in the gut, which can lead to the formation of abnormal connections called fistulas. These fistulas can occur between the GI tract and the abdominal cavity, adjacent organs, or the skin.
View Article and Find Full Text PDFPaper and Pencil Design of Color-Pure Organic Emitters: The Curious Case of Xanthene Dyes.
J Phys Chem A
January 2025
Madrid Institute for Advanced Studies, IMDEA Nanoscience, C/Faraday 9, Ciudad Universitaria de Cantoblanco, Madrid 28049, Spain.
The quest for color-pure emitters for multicolor bioimaging as well as for ultrahigh definition organic light-emitting diodes demands facile design concepts to avoid tedious synthetic or computational trial-and-error procedures. We have recently presented a simple recipe to construct color-pure blue emitters, which combines basic resonance structure and frontier molecular orbital treatments; this recipe applies to multiresonant type emitters and allows to enlarge the chemical space toward novel structural motifs. In the current work, we show that such fundamental considerations further apply to the structurally entirely different family of xanthene dyes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!