Procedures of identifying an individual on the basis of skeletal remains are of interest to anthropologists, anatomists, morphologists, physicians and criminologists. The results of such procedures are immensely significant, both from the cognitive point of view, as they allow for determining the range of variability of human traits, and from the practical standpoint, in forensic-medical procedures. The methodical aspect of the procedures represents an important problem since the reliability of the employed identification techniques determines the probability with which we can reconstruct the intravital appearance of an individual. The theoretical grounds for the criteria used for person's identification on the basis of skeletal remains are provided by the results of studies on variability of anatomic and morphologic structures and on reciprocal relations between the soft tissues and bony sublayer on which the soft tissues are distributed. Following the process of exhumation on February 12, 2007, in March, we received the skull of Father Stanisław Papczyński, the founder of the fraternity of Marian Priests, with the objective of performing an anthropological examination and reconstructing his face. The examinations were commissioned in association with the ceremony of his beatification planned for September 2007. We used the "POL-SIT Rekonstrukcja" computer-assisted system of intravital face reconstruction, which represents a universal human face reconstruction system, based on the skull pattern introduced to the computer. Computed tomography CT was performed employing a Siemens tomograph Somatom Sensation 64. The 3 D reconstruction of the skull was achieved using the "In Space" software.
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EMBO J
February 2024
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, David Geffen School of Medicine and UCLA Health, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
Impaired autophagy is known to cause mitochondrial dysfunction and heart failure, in part due to altered mitophagy and protein quality control. However, whether additional mechanisms are involved in the development of mitochondrial dysfunction and heart failure in the setting of deficient autophagic flux remains poorly explored. Here, we show that impaired autophagic flux reduces nicotinamide adenine dinucleotide (NAD) availability in cardiomyocytes.
View Article and Find Full Text PDFGastroenterology
November 2023
Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah. Electronic address:
Background & Aims: Cancers of the alimentary tract, including esophageal adenocarcinomas, colorectal cancers, and cancers of the gastric cardia, are common comorbidities of obesity. Prolonged, excessive delivery of macronutrients to the cells lining the gut can increase one's risk for these cancers by inducing imbalances in the rate of intestinal stem cell proliferation vs differentiation, which can produce polyps and other aberrant growths. We investigated whether ceramides, which are sphingolipids that serve as a signal of nutritional excess, alter stem cell behaviors to influence cancer risk.
View Article and Find Full Text PDFMol Ther
July 2022
The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
Although neurologic symptoms occur in two-thirds of lysosomal storage disorders (LSDs), for most we do not understand the mechanisms underlying brain dysfunction. A major unanswered question is if the pathogenic hallmark of LSDs, storage accumulation, induces functional defects directly or is a disease bystander. Also, for most LSDs we do not know the impact of loss of function in individual cell types.
View Article and Find Full Text PDFNat Commun
February 2022
Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Type 2 diabetes is associated with insulin resistance, impaired pancreatic β-cell insulin secretion, and nonalcoholic fatty liver disease. Tissue-specific SWELL1 ablation impairs insulin signaling in adipose, skeletal muscle, and endothelium, and impairs β-cell insulin secretion and glycemic control. Here, we show that I and SWELL1 protein are reduced in adipose and β-cells in murine and human diabetes.
View Article and Find Full Text PDFAm J Physiol Endocrinol Metab
May 2021
Division of Medical Genetics and Genomics, Department of Pediatrics, University of Iowa Hospitals & Clinics, Iowa City, Iowa.
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