Purpose: To investigate the resistance to degradation of resin modified glass-ionomer cement (RMGIC) and adhesive/composite restorations in sound and simulated caries-affected dentin of primary teeth subjected to carious challenge using a pH-cycling model and load-cycling, by means of a microtensile test.

Methods: Occlusal cavities were prepared in 60 sound exfoliated primary second molars. Half the specimens were submitted to pH-cycling to induce simulated caries lesion. The teeth were randomly restored with one of the two materials: (1) a RMGIC (Vitremer) and (2) a total-etch adhesive system (Adper Single Bond 2) followed by resin composite (Filtek Z100). After storage in distilled water at 37 degrees C for 24 hours, control group specimens were subjected to test procedures while the specimens in the experimental groups were subjected to two different aging methods: load-cycling (50,000 cycles, 90N, 3Hz) or carious challenge (pH-cycling: alternately 8 hours in demineralizing and 16 hours in remineralizing solutions, for 10 days). Teeth were sectioned into 1 mm2 beams and tested to failure under tension. ANOVA and multiple-comparisons tests were used (P<0.05).

Results: Vitremer bond strength was not altered by the condition of dentin. Conversely, Adper Single Bond 2 showed significantly lower bond strength values when bonded to simulated caries-affected dentin. Load-cycling did not influence bond strength for any of the tested materials, while carious challenge resulted in a significant decrease in microtensile bond strengths of Adper Single Bond 2, but not of Vitremer restorations.

Download full-text PDF

Source

Publication Analysis

Top Keywords

resistance degradation
8
simulated caries-affected
8
carious challenge
8
challenge ph-cycling
8
degradation bonded
4
bonded restorations
4
restorations simulated
4
caries-affected primary
4
primary dentin
4
dentin purpose
4

Similar Publications

Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis.

Plant Foods Hum Nutr

January 2025

College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, 404100, China.

Insulin resistance was considered to be the most important clinical phenotype of type 2 diabetes (T2DM). Almond is a widely-consumed nut and long-term intake was beneficial to alleviating insulin resistance in patients with T2DM. Hence, screening of anti-diabetic peptides from almond proteins was feasible based on the effectiveness of peptides in the treatment of T2DM.

View Article and Find Full Text PDF

Palmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels.

Cell Mol Life Sci

January 2025

Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Unitat de Farmacologia, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028, Barcelona, Spain.

Nuclear growth differentiation factor 15 (GDF15) reduces the binding of the mothers' against decapentaplegic homolog (SMAD) complex to its DNA-binding elements. However, the stimuli that control this process are unknown. Here, we examined whether saturated fatty acids (FA), particularly palmitate, regulate nuclear GDF15 levels and the activation of the SMAD3 pathway in human skeletal myotubes and mouse skeletal muscle, where most insulin-stimulated glucose use occurs in the whole organism.

View Article and Find Full Text PDF

HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic prospects.

Cell Mol Life Sci

January 2025

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Hypoxia, or a state of low tissue oxygenation, has been characterized as an important feature of solid tumors that is related to aggressive phenotypes. The cellular response to hypoxia is controlled by Hypoxia-inducible factors (HIFs), a family of transcription factors. HIFs promote the transcription of gene products that play a role in tumor progression including proliferation, angiogenesis, metastasis, and drug resistance.

View Article and Find Full Text PDF

The widespread use of antibiotics has led to the emergence of multidrug-resistant bacteria, which pose significant threats to animal health and food safety. Host defense peptides (HDPs) have emerged as promising alternatives because of their unique antimicrobial properties and minimal resistance induction. However, the high costs associated with HDP production and incorporation into animal management practices hinder their widespread application.

View Article and Find Full Text PDF

Some patients with metastatic castration-resistant prostate cancer (mCRPC) possess germline or acquired defects in the DNA damage repair (DDR) genes BRCA1 and BRCA2. Tumors with BRCA mutations exhibit sensitivity to poly-ADP ribose polymerase inhibitors (PARPi) such as olaparib and rucaparib. As a result, molecular diagnostic testing to identify patients with BRCA mutations eligible for the PARPi therapy has become an integral component of managing patients with mCRPC.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!