The classes of monotone or convex (and necessarily monotone) densities on ℝ(+) can be viewed as special cases of the classes of k-monotone densities on ℝ(+). These classes bridge the gap between the classes of monotone (1-monotone) and convex decreasing (2-monotone) densities for which asymptotic results are known, and the class of completely monotone (∞-monotone) densities on ℝ(+). In this paper we consider non-parametric maximum likelihood and least squares estimators of a k-monotone density g(0).We prove existence of the estimators and give characterizations. We also establish consistency properties, and show that the estimators are splines of degree k - 1 with simple knots. We further provide asymptotic minimax risk lower bounds for estimating the derivatives[Formula: see text], at a fixed point x(0) under the assumption that [Formula: see text].
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http://dx.doi.org/10.1111/j.1467-9574.2009.00438.x | DOI Listing |
Reprod Biomed Online
September 2024
UMF Iuliu Haţieganu, Cluj-Napoca, Romania.
Research Question: Are the combined genotypes and haplotypes of vitamin D receptor (VDR) gene polymorphisms (FokI, ApaI and TaqI) associated with susceptibility to polycystic ovary syndrome (PCOS) and metabolic features of the disease?
Design: This case-control study included 46 women with PCOS and 48 controls. Genotypes of the VDR gene were determined using the polymerase chain reaction-restriction fragment length polymorphism method. Waist circumference, and parameters of lipid and glucose metabolism were evaluated in all women.
J Vasc Surg
December 2024
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Objective: Whether high-density lipoprotein cholesterol (HDL-C) has a protective role against abdominal aortic aneurysm (AAA) development in both older males and females remains uncertain. This study aims to assess the sex-specific association between HDL-C and incident AAA in older adults from the UK Biobank.
Methods: This cohort study included 86,184 males and 95,682 females aged ≥60 years from the UK biobank.
Am J Ophthalmol
November 2024
Department of Ophthalmology and Visual Sciences (M.H.K., S.N., T.H.A.L., and S.J.), McGill University, Montréal, QC, Canada; Département de Ophtalmologie (A.S.P. and S.J.), Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada. Electronic address:
Medicine (Baltimore)
November 2024
Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
This study was to investigate the correlation between the number of endothelial progenitor cells (EPCs) in peripheral blood and abdominal aortic aneurysm (AAA), and provide a potential biomarker for the diagnosis and treatment monitoring of AAA. Patients with AAA evaluated in the First Affiliated Hospital of Soochow University from June 2018 to October 2018 (n = 7) were included in this study. All patients were confirmed as AAA by vascular CTA with an increase of more than 50% of the abdominal aortic diameter.
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November 2024
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Objective: Robust evidence has demonstrated that inflammation plays an important role in the occurrence and development of abdominal aortic aneurysms (AAA). The serum uric acid (UA)/high-density lipoprotein cholesterol (HDL-C) ratio (UHR) has recently been recognized as a new biomarker for evaluating inflammatory and anti-inflammatory interactions. However, whether UHR is associated with AAA remains unclear.
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