This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 × 10(6) photons/cm(2) with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860634 | PMC |
| http://dx.doi.org/10.1109/JSSC.2009.2016994 | DOI Listing |
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