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Human cumulus cells as biomarkers for embryo and pregnancy outcomes. | LitMetric

Human cumulus cells as biomarkers for embryo and pregnancy outcomes.

Mol Hum Reprod

CHU Montpellier, Institute for Research in Biotherapy, Hôpital Saint-Eloi, INSERM U847, Montpellier, France.

Published: August 2010

AI Article Synopsis

  • - Single-embryo transfer in IVF is becoming more common to lower the risks associated with multiple pregnancies, which can lead to health complications for both mothers and babies.
  • - Traditionally, the best embryos for transfer are selected based on visual features, but newer technologies, including 'omics' sciences, offer more precise methods for assessing embryos' potential for implantation.
  • - Research into the transcriptomic profile of cumulus cells, which support oocytes, is promising as it can non-invasively indicate the quality of embryos, potentially improving the success rates of IVF treatments.

Article Abstract

Single-embryo transfer is becoming increasingly common in in vitro fertilization (IVF) treatment as a means of reducing multiple pregnancy rates leading to a higher incidence of medical, perinatal and neonatal complications. Consequently, selecting embryos with the highest implantation potential is of great importance in assisted reproductive technology. To date, the choice of the best embryos to transfer is based on subjective morphological parameters. However, as judged by their subjective aspect, movement towards more sophisticated technologies to select the most competent oocytes and/or embryos with the greatest implantation potential have become available, including emerging 'omics' sciences, such as genomics, transcriptomics, proteomics and metabolomics. In this way, the study of the cumulus cells (CCs) transcriptomic profile offers the opportunity, by a non-invasive method, to predict oocyte and embryo competence because bidirectional traffic between CCs and the oocyte is very important for the acquisition of this competence. Using either RT-PCR or DNA microarrays, some studies have provided evidence for the genes expressed in CCs presenting potential biomarkers to predict embryo quality and pregnancy outcomes. This review provides an overview of the current knowledge about CCs as biomarkers for oocyte and embryo selection under an IVF program.

Download full-text PDF

Source
http://dx.doi.org/10.1093/molehr/gaq032DOI Listing

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