AI Article Synopsis
- Dendritic cells (DCs) are important for cancer immunotherapy, but their effectiveness can be limited by how well they migrate to lymph nodes after being injected.
- Researchers found that activating mast cells in the skin can enhance the movement of dendritic cells to these crucial lymph nodes, improving their ability to trigger an immune response.
- The study suggests that by using local mast cell activation techniques, we could boost the effectiveness of dendritic cell therapies in treating cancer.
Article Abstract
Dendritic cells (DCs), as potent antigen presenting cells, are increasingly used for immunotherapeutic approaches, predominantly in oncology. Low efficiency of injected Ag-pulsed DC homing to draining lymph nodes (DLNs) is one of the factors that affect the efficacy of therapy. As Langerhans cell emigration was enhanced after skin mast cell degranulation, we investigated the effect of local mast cell activation on exogenous bone marrow-derived DCs (BM-DCs) homing to DLNs. Product of activated MC/9 mast cells enhanced chemotaxis of BM-DCs to CCL21 in vitro. Intradermal injection of compound 48/80 (c48/80) induced local skin mast cell obvious degranulation and boosted exogenous BM-DC homing to DLNs. Both Ag-specific lymphocyte proliferation and TH1/TH2 cytokine production increased after HBsAg-pulsed BM-DC was injected into c48/80 pretreated mice. These results suggest that transferred DC homing to DLNs promoted by local mast cell degranulation may have potential application to improve DC-based immunotherapy.
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| http://dx.doi.org/10.1016/j.cellimm.2010.03.017 | DOI Listing |
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