While it has been shown in several publications that the serine-threonine kinase PKCtheta is required for efficient activation of mature T lymphocytes, the role of PKCtheta in T cell development in the thymus is somewhat controversial. In this study, using knockout mice, we show that PKCtheta is important in positive selection. The thymus of PKCtheta(-/-) animals contains significantly less mature single positive T cells compared to wild-type controls. Biochemically, PKCtheta deficient thymocytes show defective activation of the transcription factors AP-1, NFAT and NFkappaB as well as impaired phosphorylation of the MAP kinase ERK after T cell receptor stimulation in vitro. Together, these results reveal a crucial role of PKCtheta in positive selection of thymocytes in a pathway leading to the activation of ERK, AP-1, NFAT, and NFkappaB.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937209 | PMC |
| http://dx.doi.org/10.1016/j.imlet.2010.04.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of Contrast-Enhanced Ultrasound Parameters of Metastatic Axillary Lymph Nodes in Breast Cancer Patients in Predicting the Efficacy of Neoadjuvant Chemotherapy in Early Stage.
J Clin Ultrasound
January 2025
Inpatient Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: To investigate the performance of contrast-enhanced ultrasound(CEUS) parameters of metastatic axillary lymph nodes (ALNs) before and after two courses of neoadjuvant chemotherapy (NAC) in breast cancer patients in predicting the efficacy of NAC.
Methods: A total of 41 postoperative breast cancer patients were selected. All patients underwent NAC, and ALN biopsy was positive before chemotherapy.
Chromosome-level genome assembly of Pontederia cordata L. provides insights into its rapid adaptation and variation of flower colors.
DNA Res
January 2025
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Pontederia cordata L. is an aquatic ornamental plant native to the Americas, but has been widely distributed in South Asia, Australia, and Europe. The genetic mechanisms behind its rapid adaptation and spread have not yet been well understood.
View Article and Find Full Text PDFSelected determinants of anxiety and depression symptoms in adolescents aged 11-15 in relation to the pandemic COVID-19 and the war in Ukraine.
Front Public Health
January 2025
Department of Psychology, Kazimierz Wielki University, Bydgoszcz, Poland.
Introduction: The ongoing COVID-19 pandemic, which began in early 2020, and the outbreak of war in Ukraine in 2022 (a country bordering Poland on the east) have significantly impacted the mental health of young people in Poland, leading to increased rates of depression, anxiety, and other mental health issues. The rising number of individuals struggling to cope with daily stressors, as well as non-normative stressors, may indicate a decrease in the individual's potential, specifically in skills, attitudes, and competencies required to overcome difficulties that they encounter. It can be assumed that for young people, maintaining mental health under the influence of social stressors, such as the pandemic and the ongoing war in Ukraine, depends on the ability to adapt positively, which is the ability of young individuals to adjust to situational demands in a way that allows them to effectively manage those situations.
View Article and Find Full Text PDFRadiation knowledge and anxiety levels among residents proximity to the world's first AP1000 nuclear power unit.
Front Public Health
January 2025
Department of Occupational Health and Radiological Protection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Objective: Assess the level of radiation-related knowledge (RRK) and nuclear energy-related knowledge (NERK) among residents near the Sanmen Nuclear Power Plant, the first project adopted the Advanced Passive Pressurized Water Reactor (AP1000) technology.
Methods: In this study, respondents were selected using stratified multi-stage random sampling for residents aged 18 years and above living within 30 kilometers of the Sanmen Nuclear Power Station. Respondents were surveyed face-to-face by investigators who received standardized training.
"Breaking the Bleed" Spontaneous Hemorrhage in an Emphysematous Bulla Complicated by Anticoagulation: A Case Report.
Cureus
December 2024
Internal Medicine, Mercy Health St. Vincent Medical Center, Toledo, USA.
We present a case of spontaneous hemorrhage in an emphysematous bulla, complicated by anticoagulation. Bullous emphysema is a well-recognized complication of chronic obstructive pulmonary disease (COPD), and a rare manifestation is hemorrhage into preexisting pulmonary bullae. A 69-year-old male patient presented to the emergency department with hemoptysis, shortness of breath, and productive cough.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!