AI Article Synopsis
- The study aimed to explore how new bone forms during distraction osteogenesis (DO) used for correcting cleft palate (CP) in rhesus monkeys.
- During the experiment, 21 monkeys with surgically created CP underwent DO, with regular distractions and periodic sacrifices to examine bone development over time.
- The results showed that DO effectively closed the CP and facilitated bone maturation, highlighting the importance of fixation in the remodeling process of the newly formed bone.
Article Abstract
Objective: To investigate the mechanism of new bone formation in the distraction osteogenesis (DO) for correction of cleft palate (CP) in rhesus.
Methods: CP was created by operation in 23 rhesus. The CP was corrected with DO in 21 animals as experimental group. The distraction rate was 0.8 mm per day, two times a day. The bone fragments were fixed after cleft closure, every 3 animals were sacrificed to get specimen after 1, 2, 4, 6, 8, 12, 24 weeks of fixation. 6 days before sacrifice, tetracycline was administrated for labeling (30 mg/kg).
Results: The hard and soft tissue def of fixation. At the same time, the bone volume and calcification between the distraction gap increased. The cleft in the control group could not b ect was successfully closed with DO by intramembrane osteogenesis. The new formed bone was remodeling and became maturation during the period e corrected spontaneously.
Conclusions: The DO can successfully correct both the soft and hard tissue defect in CP by intramembrane osteogenesis. The fixation is important for remodeling and maturation of the new formed bone.
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