Objective: To study the chemical constituents and test the cytotoxicity of the purified compounds from the Thorny Elaeagnus Leaf.
Methods: The constituents were isolated by column chromatography and their structures were elucidated by chemical properties and spectroscopic analysis. The cytotoxicity of the chemical components for SGC-7901 and Hela cells was measured by MuT method.
Results: Four components were isolated and identified as 3'-O-methylquercetin( 1),kaempferol-3-O-beta-D-6-O-(p-hydroxycinnamoyl) -glucopyranoside(2), kakkalide(3),3'-O-methyl-ellagic acid-4-O-alpha-L-rhamnicoside(4). These components had cytotoxicity for SGC-7901 and Hela cells.
Conclusion: Compounds 1,3 and 4 are isolated from Thorny Elaeagnus Leaf for the first time. The results of pharmacological experiments indicate that compounds 1 and 2 show strong cytotoxicity to Hela cells.
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