Mirror movements are involuntary contralateral movements that mirror voluntary ones and are often associated with defects in midline crossing of the developing central nervous system. We studied two large families, one French Canadian and one Iranian, in which isolated congenital mirror movements were inherited as an autosomal dominant trait. We found that affected individuals carried protein-truncating mutations in DCC (deleted in colorectal carcinoma), a gene on chromosome 18q21.2 that encodes a receptor for netrin-1, a diffusible protein that helps guide axon growth across the midline. Functional analysis of the mutant DCC protein from the French Canadian family revealed a defect in netrin-1 binding. Thus, DCC has an important role in lateralization of the human nervous system.
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http://dx.doi.org/10.1126/science.1186463 | DOI Listing |
Cortex
January 2025
"Aldo Ravelli" Research Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milano, Italy; Unità di Psichiatria, Milano, Italy.
Functional Motor Disorders (FMD) consists in symptoms of altered motor function not attributable to typical neurological and medical conditions. This study aimed to explore explicit and perceptual measures of Sense of Ownership, Agency, and Body Schema in FMD patients, and assess whether these alterations are specific to FMD or shared with other functional disturbances. Twelve FMD patients, ten with Irritable Bowel Syndrome (IBS, a functional gastrointestinal disorder) and fifteen healthy controls (HC) underwent: (i) the Mirror Box Illusion (MBI), requiring participants to perform tapping movements with their dominant hand concealed from sight, while visual feedback was provided by an alien hand under visuo-motor congruency or incongruency conditions; (ii) a Forearm Bisection Task before and after exposure to the MBI, and the Embodiment Questionnaire after the MBI, as perceptual and explicit indices of the embodiment illusion, respectively.
View Article and Find Full Text PDFBraz J Phys Ther
January 2025
Institut Robert Merle d'Aubigné, Valenton, France.
Background: Mirror therapy shows promise in the treatment of phantom limb pain but lacks robust evidence.
Objectives: To address this gap, we conducted a scoping review aiming to comprehensively explore the landscape of mirror therapy practice, gather details about the session content, and offer recommendations for future research.
Method: We searched seven databases for published work from 1995 to May 2023.
Sci Rep
January 2025
Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, University of Acibadem Mehmet Ali Aydınlar, Kerem Aydinlar Kampusu, Icerenkoy Mah. Kayisdagi Cad. No: 32, Atasehir, 34752, Istanbul, Turkey.
This systematic review and meta-analysis aims to assess the effects of movement representation techniques (MRT) on pain, range of motion, functional outcomes, and pain-related fear in patients with non-specific shoulder pain (NSSP). A literature search conducted in PubMed, PEDro, EBSCO, Scopus, Cochrane Library, ScienceDirect, and gray literature on April 31, 2023. We selected seven randomized controlled trials based on the PICOS framework.
View Article and Find Full Text PDFConscious Cogn
January 2025
Faculty of Human-Environment Studies, Kyushu University, Fukuoka, Japan.
The aim of the current study was to investigate visual scan patterns for the self-face in infants with the ability to recognize themselves with a photograph. 24-month-old infants (N = 32) were presented with faces including the self-face in the upright or inverted orientation. We also measured infants' ability to recognize oneself in a mirror and with a photograph.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Italy.
Paratonia is an involuntary muscle activity that occurs during passive joint mobilization and is common in people with dementia. It includes oppositional paratonia, in which muscle activity resists passive movement, and facilitatory paratonia, in which it assists movement. This phenomenon reflects a defect in motor response inhibition.
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