Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) are among the most prevalent dementias and they often show specific patterns of cognitive dysfunction. This study examined whether differences exist between groups on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) that could assist with differential diagnosis. The examiners utilized the NINCDS-ADRDA and the NINDS-AIREN criteria to identify 39 probable AD and 29 probable SVaD patients. A battery of neuropsychological tests was performed and neuroimaging was reviewed for all subjects. Analyses revealed that the SVaD group performed significantly better on the Delayed Memory Index (DMI) and its subtests measuring Recognition, Contextual Memory, and Figure Recall. In contrast to previous research, there were no differences between groups on immediate memory tasks, and post hoc analyses revealed no differences on any other index or subtest. The results also suggested that the DMI and its subtests and the Story Memory subtest of the Immediate Memory Index have better sensitivity to AD, better specificity to SVaD, and roughly equivalent positive predictive power compared with other components of the RBANS. Overall, findings suggest that the indices and subtests of the RBANS may be limited in differentiating AD versus SVaD, except for the DMI and its subtests.
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Predicting biomarkers in intact older adults and those with amnestic Mild Cognitive Impairment, and mild Alzheimer's Disease using the Repeatable Battery for the Assessment of Neuropsychological Status.
J Clin Exp Neuropsychol
November 2021
Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Introduction: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been associated, to varying degrees, with commonly used biomarkers of Alzheimer's disease (AD). Given the ease of RBANS administration as a screening tool for clinical trials and other applications, a better understanding of how RBANS performance is associated with presence of APOE ε4 allele[s], cerebral amyloid burden, and hippocampal volume is warranted.
Method: One hundred twenty-one older adults who were classified as intact, amnestic Mild Cognitive Impairment, or mild AD underwent cognitive assessment with the RBANS, genetic analysis, and quantitative brain imaging.
RBANS memory percentage retention: No evidence of incremental validity beyond RBANS scores for diagnostic classification of mild cognitive impairment and dementia and for prediction of daily function.
Appl Neuropsychol Adult
April 2018
b Canadian Centre for Health and Safety in Agriculture, Medicine , University of Saskatchewan, Saskatoon , Saskatchewan , Canada.
RBANS percentage retention scores may be useful for diagnosis, but their incremental validity is unclear. Percentage retention versus RBANS immediate and delayed memory subtests and delayed index scores were compared for diagnostic classification and for prediction of function. Data from 173 memory clinic patients with an interdisciplinary diagnosis (no cognitive impairment, amnestic mild cognitive impairment [aMCI], and dementia due to Alzheimer's disease [AD]) and complete RBANS data were analyzed.
View Article and Find Full Text PDFSubstitution of California Verbal Learning Test, second edition for Verbal Paired Associates on the Wechsler Memory Scale, fourth edition.
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Department of Psychology, Wayne State University, Detroit, MI, USA.
Two common measures used to evaluate verbal learning and memory are the Verbal Paired Associates (VPA) subtest from the Wechsler Memory Scales (WMS) and the second edition of the California Verbal Learning Test (CVLT-II). For the fourth edition of the WMS, scores from the CVLT-II can be substituted for VPA; the present study sought to examine the validity of the substitution. For each substitution, paired-samples t tests were conducted between original VPA scaled scores and scaled scores obtained from the CVLT-II substitution to evaluate comparability.
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Research on previous versions of the Wechsler Memory Scale (WMS) found that index scores could be predicted using a parsimonious selection of subtests (e.g., Axelrod & Woodard, 2000).
View Article and Find Full Text PDFAre the indices of the RBANS sufficient for differentiating Alzheimer's disease and subcortical vascular dementia?
Arch Clin Neuropsychol
June 2010
Argosy University, Atlanta, GA 30328, USA.
Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) are among the most prevalent dementias and they often show specific patterns of cognitive dysfunction. This study examined whether differences exist between groups on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) that could assist with differential diagnosis. The examiners utilized the NINCDS-ADRDA and the NINDS-AIREN criteria to identify 39 probable AD and 29 probable SVaD patients.
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