Repeated angioedema following administration of venlafaxine and mirtazapine.

We report a rare case of a 48-year-old female who presented with bilateral lower-leg swelling due to a medication-induced angioedema resulting from the use of two common classes of antidepressants, venlafaxine and mirtazapine. Although the mechanisms by which the antidepressants achieve these effects are not understood, the recent recognition of a novel antidepressant-dependent form of angioedema may offer important insights into the mechanisms by which the antidepressants exert their effects.