AI Article Synopsis
- The study aimed to investigate changes in apoptosis in the dilator muscles of the upper airway, particularly looking at Bax and Bcl-2 expression in the tensor veli palatini of patients with Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS).
- The findings revealed that Bax levels were significantly higher in OSAHS patients compared to those with chronic tonsillitis, while Bcl-2 levels showed no significant difference.
- Additionally, a strong positive correlation was found between the Apnea-Hypopnea Index (AHI) and Bax expression, indicating that increased severity of OSAHS is linked to greater apoptosis in this muscle.
Article Abstract
Objective: To explore apoptosis changes of dilator muscles in the upper airway by detecting the expression of Bax, Bcl-2 in tensor veli palatini in patients with OSAHS.
Method: The expression of Bax and Bcl-2 were detected in tensor veli palatini in 30 cases with OSAHS and 10 cases chronic tonsillitis without OSAHS by immunohistochemistry and image analytical system, and the results were analyzed.
Result: (1) The expression levels of Bax in the OSAHS group increased significantly compared to control group (P < 0.05), but there were no significant differences of Bcl-2 expression between two groups, the ratio of Bax/Bcl-2 increased significantly (P < 0.05). (2) There were positive correlations between AHI and the expression levels of Bax (r = 0.697, P < 0.01) respectively in the test group.
Conclusion: The results indicate that apoptosis occurred in tensor veli palatini in patients with OS AHS, and the more severity of OSAHS, the more apoptosis.
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