Access to original vinylic chlorides in the quinazoline series via a monoelectronic transfer reaction approach.

Molecules

Laboratoire de Pharmacochimie Radicalaire, Faculté de Pharmacie, Universités d'Aix-Marseille I, II et III - UMR CNRS 6264, Laboratoire Chimie Provence, 27 Boulevard Jean Moulin, Marseille cedex 05, France.

Published: April 2010

AI Article Synopsis

  • Researchers developed new quinazoline compounds that have a vinylic chloride group attached to the 2-position.
  • The compounds were created using a two-step process that involves both substitution and elimination reactions through radical mechanisms.
  • This innovative approach could lead to new applications or enhancements in the properties of quinazoline derivatives.

Article Abstract

A series of new quinazoline derivatives bearing a vinylic chloride group on the 2-position was prepared by using a consecutive S(RN)1 / E(RC)1 radical strategy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257244PMC
http://dx.doi.org/10.3390/molecules15042719DOI Listing

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